Kim Sung-hoon (biologist)

Sunghoon Kim
Born

1958 (age 57–58)


South Korea

Residence Seoul, South Korea
Nationality South Korean
Fields Aminoacyl-tRNA synthetase, Translation, Cancer biology, Therapeutic target discovery
Institutions Seoul National University
Alma mater Ph.D. Brown University, U.S.
Doctoral advisor Dr. Arthur Landy
Known for Aminoacyl-tRNA Synthetases
Notable awards

The National Presidential Award, Ministry of Science and Technology (2003)

The Scientist of the Month, Korea Science and Engineering Foundation(KOSEF) (2003)
The Best Scientist of the Year, Ministry of Science and Technology(2006)
The Award of Korean National Academy of Science (2012)
Kim Sung-hoon
Hangul 김성훈
Revised Romanization Gim Seong-hun
McCune–Reischauer Kim Sŏnghun

Dr. Kim Sunghoon is a South Korean biologist.

Education

Work

Dr. Sunghoon Kim has been studying novel functions of human aminoacyl-tRNA synthetases(ARSs) and searching for their pathophysiological connections to human diseases(PNAS 105:11043,[1] 2008; Nat Rev Cancer 11:708, 2011[2]). He has identified potent novel tumor suppressors such as AIMP2/p38(Nat Genet 34:330, 2003[3]), AIMP3/p18(Cell, 120:209, 2005[4]). Besides, he has also investigated novel extracellular activities of ARSs and associated factors such as lysyl-tRNA synthetase(KRS)(PNAS 102, 6356, 2005[5]), tryptophanyl-tRNA synthetase(WRS)(Nat Struct Mol Biol 11:149, 2004[6]) and AIMP1/p43(PNAS 103:14913, 2006[7]). He also discovered the oncogenic variant of AIMP2, designated AIMP2-DX2, as one of the critical factors that determines the survival of lung cancer patients(Plos Genet 7:e1001351, 2011[8]). More recently, he found that leucyl-tRNA synthetase(LRS) serves as an amino acid sensor for mTOR signal pathway(Cell 149:410, 2012[9]).

In summary, his research is unveiling novel regulatory network mediated by human aminoacyl-tRNA synthetases that have been regarded as housekeeping machinery for protein synthesis. The regulatory roles and implications of these proteins in human diseases have been largely overlooked for decades. His series of the discoveries on the new function, pathology and medicine of ARSs are rapidly opening a research area that throws new insights into the central dogma of life and human diseases.

Awards

See also

References

  1. ↑ Aminoacyl tRNA synthetases and their connections to disease
  2. ↑ http://www.nature.com/nrc/journal/v11/n10/full/nrc3124.html
  3. ↑ http://www.nature.com/ng/journal/v34/n3/full/ng1182.html
  4. ↑ Cell - The Haploinsufficient Tumor Suppressor p18 Upregulates p53 via Interactions with ATM/ATR
  5. ↑ Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response
  6. ↑ http://www.nature.com/nsmb/journal/v11/n2/full/nsmb722.html
  7. ↑ Hormonal activity of AIMP1/p43 for glucose homeostasis
  8. ↑ PLOS Genetics: Cancer-Associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis
  9. ↑ Cell - Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway
  10. ↑ KOFST 한국과학기술단체총연합회
  11. ↑ NAS Award : Activities : The National Academy Of Sciences Republic Of Korea

External links


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