LMO3

LMO3
Identifiers
Aliases	LMO3, RBTN3, RBTNL2, RHOM3, Rhom-3, LIM domain only 3
External IDs	HomoloGene: 136507 GeneCards: LMO3
Gene ontology Molecular function • zinc ion binding • protein binding • metal ion binding Cellular component • cytoplasm Biological process • negative regulation of ERK1 and ERK2 cascade • regulation of transcription, DNA-templated • positive regulation of fat cell differentiation • positive regulation of glucocorticoid receptor signaling pathway • transcription, DNA-templated • positive regulation of peroxisome proliferator activated receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55885	n/a
Ensembl	ENSG00000048540	n/a
UniProt	Q8TAP4	n/a
RefSeq (mRNA)	NM_001001395 NM_001243609 NM_001243610 NM_001243611 NM_001243612 NM_001243613 NM_018640	n/a
RefSeq (protein)	NP_001001395.1 NP_001230538.1 NP_001230539.1 NP_001230540.1 NP_001230541.1 NP_001230542.1 NP_061110.2	n/a
Location (UCSC)	Chr 12: 16.55 – 16.61 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

LIM domain only protein 3 is a transcription co-factor, which in humans is encoded by the LMO3 gene.^[2][3][4] LMO3 interacts with the tumor suppressor p53 and regulates its function.^[5] LMO3 is considered to be an oncogene in Neuroblastoma.^[6]

References

1. "Human PubMed Reference:".
2. Larsen, Steven; Yokochi, Tomoki; Isogai, Eriko; Nakamura, Yohko; Ozaki, Toshinori; Nakagawara, Akira (2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.
3. Shi, J; Cai, W; Chen, X; Ying, K; Zhang, K; Xie, Y (2001). "Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization". Brain Research. 910 (1–2): 29–37. doi:10.1016/S0006-8993(01)02393-9. PMID 11489251.
4. EntrezGene 55885
5. Larsen, Steven; Yokochi, Tomoki; Isogai, Eriko; Nakamura, Yohko; Ozaki, Toshinori; Nakagawara, Akira (2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.
6. Larsen, Steven; Yokochi, Tomoki; Isogai, Eriko; Nakamura, Yohko; Ozaki, Toshinori; Nakagawara, Akira (2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.

Further reading

• Friedel, S; Saar, K; Sauer, S; Dempfle, A; Walitza, S; Renner, T; Romanos, M; Freitag, C; et al. (2007). "Association and linkage of allelic variants of the dopamine transporter gene in ADHD". Molecular Psychiatry. 12 (10): 923–33. doi:10.1038/sj.mp.4001986. PMID 17579611.
• Davis, Caroline; Levitan, Robert D; Kaplan, Allan S; Carter, Jacqueline; Reid, Caroline; Curtis, Claire; Patte, Karen; Kennedy, James L (2007). "Dopamine Transporter Gene (DAT1) Associated with Appetite Suppression to Methylphenidate in a Case–Control Study of Binge Eating Disorder". Neuropsychopharmacology. 32 (10): 2199–206. doi:10.1038/sj.npp.1301348. PMID 17314918.
• Lim, Janghoo; Hao, Tong; Shaw, Chad; Patel, Akash J.; Szabó, Gábor; Rual, Jean-François; Fisk, C. Joseph; Li, Ning; et al. (2006). "A Protein–Protein Interaction Network for Human Inherited Ataxias and Disorders of Purkinje Cell Degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Rual, Jean-François; Venkatesan, Kavitha; Hao, Tong; Hirozane-Kishikawa, Tomoko; Dricot, Amélie; Li, Ning; Berriz, Gabriel F.; Gibbons, Francis D.; et al. (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Aoyama, M.; Ozaki, T; Inuzuka, H; Tomotsune, D; Hirato, J; Okamoto, Y; Tokita, H; Ohira, M; et al. (2005). "LMO3 Interacts with Neuronal Transcription Factor, HEN2, and Acts as an Oncogene in Neuroblastoma". Cancer Research. 65 (11): 4587–97. doi:10.1158/0008-5472.CAN-04-4630. PMID 15930276.
• Gerhard, DS; Wagner, L; Feingold, EA; Shenmen, CM; Grouse, LH; Schuler, G; Klein, SL; Old, S; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Research. 14 (10b): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota, Toshio; Suzuki, Yutaka; Nishikawa, Tetsuo; Otsuki, Tetsuji; Sugiyama, Tomoyasu; Irie, Ryotaro; Wakamatsu, Ai; Hayashi, Koji; et al. (2003). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Mammalian Gene Collection Program Team* (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Foroni, L; Boehm, T; White, L; Forster, A; Sherrington, P; Liao, XB; Brannan, CI; Jenkins, NA; et al. (1992). "The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development*1". Journal of Molecular Biology. 226 (3): 747–61. doi:10.1016/0022-2836(92)90630-3. PMID 1507224.