Lactate permease family
| Lactate permease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | LctP | ||||||||
| Pfam | PF02652 | ||||||||
| InterPro | IPR003804 | ||||||||
| TCDB | 2.A.14 | ||||||||
| |||||||||
The lactate permease (LctP) family (TC# 2.A.14) is a family of transport proteins belonging to the ion transporter (IT) superfamily.[1] Proteins of the LctP family have been found in Gram-negative and Gram-positive bacteria as well as archaea.[2]
Function
One member of the LctP family, from E. coli, is a lactate:H+ symporter.[3] Two closely related paralogues have been found encoded within the E. coli genome (LctP and GlcA, TC# 2.A.14.1.1 and TC# 2.A.14.1.2, respectively), and one of these has been shown to be the glycolate uptake permease (GlcA).[4] Both permeases transport the same acids (L- and D-lactate as well as glycolate), but their physiological substrates differ. The lactate permease transports both L- and D-lactate while the glycolate permease transports glycolate under physiological conditions. Regulatory effects determine the substrates transported in vivo. Characterized members of this family possess 15-18 transmembrane segments (TMSs) and are roughly 460-565 amino acyl residues in length.
General transport reaction
Transport reactions catalyzed by functionally characterized members of the LctP family include:[2]
D- or L-lactate or glycolate (out) + H+ (out) → D- or L-lactate or glycolate (in) + H+ (in).
References
- ↑ Prakash, Shraddha; Cooper, Garret; Singhi, Soumya; Saier, Milton H. (2003-12-03). "The ion transporter superfamily". Biochimica et Biophysica Acta. 1618 (1): 79–92. doi:10.1016/j.bbamem.2003.10.010. ISSN 0006-3002. PMID 14643936.
- 1 2 "2.A.14 The Lactate Permease (LctP) Family". Transporter Classification Database. Retrieved 2016-03-02.
- ↑ Dong, J. M.; Taylor, J. S.; Latour, D. J.; Iuchi, S.; Lin, E. C. (1993-10-01). "Three overlapping lct genes involved in L-lactate utilization by Escherichia coli". Journal of Bacteriology. 175 (20): 6671–6678. ISSN 0021-9193. PMC 206779
. PMID 8407843. - ↑ Núñez, M. F.; Pellicer, M. T.; Badía, J.; Aguilar, J.; Baldomà, L. (2001-04-01). "The gene yghK linked to the glc operon of Escherichia coli encodes a permease for glycolate that is structurally and functionally similar to L-lactate permease". Microbiology (Reading, England). 147 (Pt 4): 1069–1077. doi:10.1099/00221287-147-4-1069. ISSN 1350-0872. PMID 11283302.
Further reading
- Moraes, Trevor F.; Reithmeier, Reinhart A. F. (2012-11-01). "Membrane transport metabolons".Biochimica et Biophysica Acta 1818 (11): 2687–2706.doi:10.1016/j.bbamem.2012.06.007. ISSN 0006-3002.PMID 22705263.
- Núñez, María Felisa; Kwon, Ohsuk; Wilson, T. Hastings; Aguilar, Juan; Baldoma, Laura; Lin, Edmund C. C. (2002-01-18). "Transport of L-Lactate, D-Lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli". Biochemical and Biophysical Research Communications 290 (2): 824–829.doi:10.1006/bbrc.2001.6255. ISSN 0006-291X.PMID 11785976.
- Rabus, R.; Jack, D. L.; Kelly, D. J.; Saier, M. H. (1999-12-01). "TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters". Microbiology (Reading, England). 145 ( Pt 12): 3431–3445. doi:10.1099/00221287-145-12-3431.ISSN 1350-0872. PMID 10627041.
- Saier, M. H.; Eng, B. H.; Fard, S.; Garg, J.; Haggerty, D. A.; Hutchinson, W. J.; Jack, D. L.; Lai, E. C.; Liu, H. J. (1999-02-25). "Phylogenetic characterization of novel transport protein families revealed by genome analyses". Biochimica et Biophysica Acta 1422 (1): 1–56.ISSN 0006-3002. PMID 10082980.
As of 12 March 2016, this article is derived in whole or in part from Transporter Classification Database. The copyright holder has licensed the content in a manner that permits reuse under CC BY-SA 3.0 and GFDL. All relevant terms must be followed. The original text was at "2.A.14 The Lactate Permease (LctP) Family".