Local hormone

Local hormones, by one definition, are biologically active polypeptides that are secreted by nerve cells and gland cells and act in a paracrine fashion but also enter the circulary another definition, local hormones are any hormones acting in a paracrine, autocrine, and/or intracrine manner.

Classification

According to structural and functional similarity, many local hormones fall into either the gastrin or the secretin family.

Gastrin family

  1. Gastrin
  2. Cholecystokinin (CCK)

Secretin family

  1. Secretin
  2. Glucagon
  3. Glicentin (GLI)
  4. Vasoactive intestinal peptide (VIP)
  5. Gastric inhibitory polypeptide (GIP)

Others

  1. Motilin
  2. Neurotensin
  3. Substance P
  4. Somatostatin
  5. Bombesin
  6. Serotonin


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