Luis E. Miramontes

Luis E. Miramontes

Luis E. Miramontes c. 1953
Born Luis Ernesto Miramontes Cárdenas
(1925-03-16)16 March 1925
Tepic, Nayarit, Mexico
Died 13 September 2004(2004-09-13) (aged 79)
Mexico City, Mexico
Residence Mexico (Nayarit, Estado de Mexico, DF)
Citizenship
  • Mexican
Fields Chemistry, chemical engineering
Institutions
Alma mater
Known for
Notable awards
  • Mexican National Prize in Chemistry (1986)
  • Top Chemical Engineer of all times (2011)

Luis Ernesto Miramontes Cárdenas (March 16, 1925 – September 13, 2004) was a Mexican chemist known as the co-inventor of the progestin norethisterone used in one of the first three oral contraceptives.

Miramontes was born at Tepic, Nayarit. He obtained his first Degree in chemical engineering in the Universidad Nacional Autónoma de México (UNAM). He was a founding researcher of the Institute of Chemistry of UNAM, specializing mainly in the area of Organic Chemistry. He was a professor of the Faculty of Chemistry of UNAM, Director and professor of the School of Chemistry at the Universidad Iberoamericana, and deputy Director of Research at the Mexican Institute of Petroleum (IMP). Miramontes was a member of diverse scientific societies, such as the American Chemical Society (Emeritus), the Mexican Institute of Chemical Engineers, the National Institute of Chemical and Chemical Engineers, the Chemical Society of Mexico, the American Institute of Chemical Engineers and the New York Academy of Sciences.

He died in Mexico City in 2004.

Invention and synthesis of norethisterone

The scientific contributions of Luis Miramontes are extensive, including numerous publications and nearly 40 national and international patents in different areas such as organic chemistry, pharmaceutical chemistry, petrochemistry and atmospheric chemistry and polluting agents. Among his multiple contributions to world science is the synthesis on October 15, 1951, when Miramontes was only 26 years old, of norethisterone (norethindrone), that was to become the progestin used in one of the first three oral contraceptives (combined oral contraceptive pills). For this reason, Luis Miramontes is considered by Lilia Miramontes to be its inventor.[1] Carl Djerassi, Luis Miramontes and George Rosenkranz of the Mexican chemical company Syntex are listed on the patent for norethisterone as its co-inventors. Djerassi "is now known sometimes as the 'Father of the Pill'".[2] The historians, nevertheless, agree that the invention, or the first synthesis, is the work of Djerassi, Miramontes, and Rosenkranz.[3][4] For example, the Nobel laureate Max Perutz[5] states that "On October 15th, 1951, the chemistry student Luis Miramontes, working under the direction of Djerassi and the director of the laboratory Jorge Rosenkranz synthesized the compound". Djerassi himself affirms that it was, in fact, Miramontes who conducted the very last step of the first synthesis of the compound: "On 15 October 1951, Luis Miramontes, a young Mexican chemist doing his undergraduate bachelor's thesis work at Syntex completed the synthesis of the 19-nor-17α-ethynyltestosterone or, for short 'norethisterone'—which turned out to be the first oral contraceptive to be synthesized. Lecture audiences are always intrigued when I display a slide showing the carefully dated and hand-written lab protocol of the very last step in that synthesis conducted by Miramontes, in which the elements of acetylene are added to impart oral activity."[6] The scientific article reporting the synthesis of 19-nor-17α-ethynyltestosterone (norethisterone) has Miramontes as the second author.[7] Finally, the very last step of the synthesis method was registered, on October 15, 1951, in page 114 of the Miramontes's personal laboratory notebook (signed).

In a 2006 essay in the FASEB Journal, the director of the Worcester Foundation for Experimental Biology said: "Another aspect of the Nobel Prizes that is a perennial topic of discussion concerns those discoveries, inventions, or advances that go unrecognized altogether. One is the birth control pill. I have just mentioned the Worcester Foundation for Biomedical Research, where pioneering work by Gregory Pincus and M. C. Chang was carried out in the 1950s that led to the first birth control pill. Pincus died in 1967—-at the tragic age of only 63, but I doubt that a Nobel Prize would have been awarded in any case. The tributaries flowing into the development of the oral contraceptive were numerous and temporally distributed across two decades, going back to the extraction of a substance from the roots of a jungle plant by Russell Marker that was readily convertible to pregnanediol and then to progesterone in two steps, the subsequent chemical synthesis of progestins by Carl Djerassi, Luis Miramontes, and George Rosenkranz, and the discovery by Gregory Pincus and M.C. Chang at the Worcester Foundation that a compound sent to be tested by the G. D. Searle Pharmaceutical Company was, contrary to expectations, a potent anti-ovulatory progestin."[8]

Recognition

Patent of the first oral contraceptive, elected to the USA Inventors Hall of Fame.
Luis E. Miramontes (right) with Nobel Laureate Mario Molina, ca. 1995

Luis E. Miramontes, Andres Manuel del Rio (discoverer of vanadium) and Mario Molina, Chemistry Nobel Prize in 1995, are the three most important Mexican chemists of all time.

Patented inventions

References

  1. ↑ Lilia Miramontes. Un invento que cambió al mundo. ¿Cómo ves? Año 8 No. 67 2004
  2. 1 2 Penny Le Couteur & Jay Burreson. Napoleon's Buttons. Tarcher; Reprint edition (May 24, 2004)
  3. ↑ Archived April 27, 2006, at the Wayback Machine.
  4. ↑ licea.PDF Archived June 16, 2007, at the Wayback Machine.
  5. ↑ Max F. Perutz. I Wish I’d Made You Angry Earlier: Essays on Science, Scientists, and Humanity. Cold Spring Harbor Laboratory Press 1998.
  6. ↑ Carl Djerassi. This Man's Pill: Reflections on the 50th Birthday of the Pill. Oxford University Press 2001.
  7. ↑ Djerassi C, Miramontes L, Rosenkranz G, Sondheimer F (1954). "Steroids. LIV. Synthesis of 19-Nor-17α-ethynyltestosterone and 19-Nor-17α-methyltestosterone" (– Scholar search). J Am Chem Soc. 76 (16): 4089–4091. doi:10.1021/ja01645a009.
  8. ↑ Pederson T (2006). "Reflections on the prize of prizes: Alfred Nobel" (PDF). FASEB J. 20 (13): 2186–9. doi:10.1096/fj.06-1102ufm. PMID 17077294.
  9. ↑ John Brockman, editor. The Greatest Inventions of the Past 2000 Years. Phoenix. 2000
  10. ↑ "BBC Mundo - Ciencia y Tecnología - Latinoamericanos que cambiaron el mundo". Bbc.co.uk. 1970-01-01. Retrieved 2013-10-14.
  11. ↑ "Aporte historico y revolucionario de un egresado de la DQ" (PDF) (in Spanish). Quimica.unam.mx. Retrieved 2013-10-14.
  12. ↑ "Quimiunam". Cienciasquimicas.posgrado.unam.mx. Retrieved 2013-10-14.
  13. ↑ Archived March 20, 2011, at the Wayback Machine.
  14. ↑
  15. ↑ "Haber and Bosch named top chemical engineers". Icheme.org. 2011-02-21. Retrieved 2013-10-14.
  16. ↑ "Ing. Luis E. Miramontes". Imiq.com.mx. Retrieved 2013-10-14.
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