MAGOH

MAGOH
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases MAGOH, MAGOH1, MAGOHA, mago homolog, exon junction complex core component
External IDs MGI: 1330312 HomoloGene: 1776 GeneCards: MAGOH
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

4116

17149

Ensembl

ENSG00000162385

ENSMUSG00000028609

UniProt

P61326

P61327

RefSeq (mRNA)

NM_002370

NM_001282737

RefSeq (protein)

NP_002361.1

NP_001269666.1

Location (UCSC) Chr 1: 53.23 – 53.24 Mb Chr 4: 107.88 – 107.89 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Protein mago nashi homolog is a protein that in humans is encoded by the MAGOH gene.[3][4]

Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.[4]

Interactions

MAGOH has been shown to interact with RBM8A[5][6] and NXF1.[6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Zhao XF, Colaizzo-Anas T, Nowak NJ, Shows TB, Elliott RW, Aplan PD (April 1998). "The mammalian homologue of mago nashi encodes a serum-inducible protein". Genomics. 47 (2): 319–22. doi:10.1006/geno.1997.5126. PMID 9479507.
  4. 1 2 "Entrez Gene: MAGOH mago-nashi homolog, proliferation-associated (Drosophila)".
  5. Zhao, X F; Nowak N J; Shows T B; Aplan P D (January 2000). "MAGOH interacts with a novel RNA-binding protein". Genomics. UNITED STATES. 63 (1): 145–8. doi:10.1006/geno.1999.6064. ISSN 0888-7543. PMID 10662555.
  6. 1 2 Kataoka, N; Diem M D; Kim V N; Yong J; Dreyfuss G (November 2001). "Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex". EMBO J. England. 20 (22): 6424–33. doi:10.1093/emboj/20.22.6424. ISSN 0261-4189. PMC 125744Freely accessible. PMID 11707413.

Further reading


This article is issued from Wikipedia - version of the 6/2/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.