Myelin-associated glycoprotein

MAG
Identifiers
Aliases	MAG, GMA, S-SIGLEC-4A, SIGLEC4A, SPG75, myelin associated glycoprotein
External IDs	OMIM: 159460 MGI: 96912 HomoloGene: 1771 GeneCards: MAG
Gene ontology Molecular function • receptor binding • protein kinase binding • carbohydrate binding Cellular component • cytoplasm • integral component of membrane • membrane • myelin sheath • myelin sheath adaxonal region • Schmidt-Lanterman incisure • paranode region of axon • mesaxon • plasma membrane Biological process • negative regulation of neuron projection development • negative regulation of neuron differentiation • substantia nigra development • positive regulation of astrocyte differentiation • nervous system development • positive regulation of myelination • cellular response to mechanical stimulus • negative regulation of axonogenesis • cell adhesion • leukocyte migration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4099	17136
Ensembl	ENSG00000105695	ENSMUSG00000036634
UniProt	P20916	P20917
RefSeq (mRNA)	NM_080600 NM_001199216 NM_002361	NM_010758
RefSeq (protein)	NP_001186145.1 NP_002352.1 NP_542167.1	NP_034888.1
Location (UCSC)	Chr 19: 35.29 – 35.31 Mb	Chr 7: 30.9 – 30.91 Mb
PubMed search	[1]	[2]
Wikidata

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myelin associated glycoprotein
Identifiers
Symbol	MAG
Alt. symbols	GMA
Entrez	4099
HUGO	6783
OMIM	159460
RefSeq	NM_080600
UniProt	P20916
Other data
Locus	Chr. 19 q13.1

Myelin-associated glycoprotein (MAG, Siglec-4) is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR.^[3] MAG is believed to be involved in myelination during nerve regeneration.^[4]

See also

• Myelin

External links

• Myelin-associated glycoprotein at the US National Library of Medicine Medical Subject Headings (MeSH)

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Quarles RH (2007). "Myelin-associated glycoprotein (MAG): past, present and beyond". Journal of Neurochemistry. 100 (6): 1431–48. doi:10.1111/j.1471-4159.2006.04319.x. PMID 17241126.
4. Barton D, Arquint M, Roder J, Dunn R, Francke U (1987). "The myelin-associated glycoprotein gene: mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice". Genomics. 1 (2): 107–12. doi:10.1016/0888-7543(87)90002-4. PMID 2447011.