KMT2E

KMT2E
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LV9, 4L58
Identifiers
Aliases	KMT2E, HDCMC04P, MLL5, NKp44L, lysine methyltransferase 2E
External IDs	MGI: 1924825 HomoloGene: 18822 GeneCards: KMT2E
Gene ontology Molecular function • methyltransferase activity • transferase activity • transcription coactivator activity • zinc ion binding • histone methyltransferase activity (H3-K4 specific) • metal ion binding • protein binding • enzyme binding • histone-lysine N-methyltransferase activity Cellular component • cytoplasm • nuclear speck • intracellular membrane-bounded organelle • membrane • plasma membrane • nucleoplasm • intercellular bridge • MLL5-L complex • nucleus Biological process • cellular response to retinoic acid • neutrophil activation • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of transcription, DNA-templated • DNA methylation • histone H3-K4 methylation • methylation • retinoic acid receptor signaling pathway • cell cycle arrest • positive regulation of granulocyte differentiation • erythrocyte differentiation • cell cycle • neutrophil mediated immunity • covalent chromatin modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55904	69188
Ensembl	ENSG00000005483	ENSMUSG00000029004
UniProt	Q8IZD2	Q3UG20
RefSeq (mRNA)	NM_018682 NM_032187 NM_182931	NM_026984
RefSeq (protein)	NP_061152.3 NP_891847.1	NP_081260.1
Location (UCSC)	Chr 7: 105.01 – 105.11 Mb	Chr 5: 23.43 – 23.5 Mb
PubMed search	[1]	[2]
Wikidata

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View/Edit Mouse

Lysine methyltransferase 2E is a protein that in humans is encoded by the KMT2E gene. ^[3]

Function

This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Lysine methyltransferase 2E". Retrieved 2016-06-02.

Further reading

• Emerling BM, Bonifas J, Kratz CP, Donovan S, Taylor BR, Green ED, Le Beau MM, Shannon KM (2002). "MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia". Oncogene. 21 (31): 4849–54. doi:10.1038/sj.onc.1205615. PMID 12101424.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.