MPDU1

MPDU1
Identifiers
Aliases	MPDU1, CDGIF, HBEBP2BPA, Lec35, My008, PP3958, PQLC5, SL15, mannose-P-dolichol utilization defect 1
External IDs	MGI: 1346040 HomoloGene: 3581 GeneCards: MPDU1
Gene ontology Molecular function • protein binding Cellular component • integral component of membrane • extracellular exosome • endoplasmic reticulum membrane • endoplasmic reticulum • mitochondrion • membrane Biological process • dolichol-linked oligosaccharide biosynthetic process • oligosaccharide biosynthetic process • protein folding • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9526	24070
Ensembl	ENSG00000129255	ENSMUSG00000018761
UniProt	O75352	Q9R0Q9
RefSeq (mRNA)	NM_004870	NM_001301710 NM_001301711 NM_011900
RefSeq (protein)	NP_004861.2	n/a
Location (UCSC)	Chr 17: 7.58 – 7.59 Mb	Chr 11: 69.66 – 69.66 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Mannose-P-dolichol utilization defect 1 protein is a protein that in humans is encoded by the MPDU1 gene.^[3][4][5][6]

See also

• Dolichol monophosphate mannose
• Congenital disorder of glycosylation

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Ware FE, Lehrman MA (Aug 1996). "Expression cloning of a novel suppressor of the Lec15 and Lec35 glycosylation mutations of Chinese hamster ovary cells". J Biol Chem. 271 (24): 13935–8. doi:10.1074/jbc.271.24.13935. PMID 8663248.
4. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
5. Schenk B, Imbach T, Frank CG, Grubenmann CE, Raymond GV, Hurvitz H, Korn-Lubetzki I, Revel-Vik S, Raas-Rotschild A, Luder AS, Jaeken J, Berger EG, Matthijs G, Hennet T, Aebi M (Dec 2001). "MPDU1 mutations underlie a novel human congenital disorder of glycosylation, designated type If". J Clin Invest. 108 (11): 1687–95. doi:10.1172/JCI13419. PMC 200989. PMID 11733564.
6. "Entrez Gene: MPDU1 mannose-P-dolichol utilization defect 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Anand M, Rush JS, Ray S, et al. (2001). "Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals.". Mol. Biol. Cell. 12 (2): 487–501. doi:10.1091/mbc.12.2.487. PMC 30958. PMID 11179430.
• Kranz C, Denecke J, Lehrman MA, et al. (2002). "A mutation in the human MPDU1 gene causes congenital disorder of glycosylation type If (CDG-If).". J. Clin. Invest. 108 (11): 1613–9. doi:10.1172/JCI13635. PMC 200991. PMID 11733556.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.". J. Steroid Biochem. Mol. Biol. 94 (1-3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview