MRPL33

MRPL33
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL33, C2orf1, L33mt, MRP-L33, RPL33L, mitochondrial ribosomal protein L33
External IDs	MGI: 2137225 HomoloGene: 81733 GeneCards: MRPL33
Gene ontology Molecular function • structural constituent of ribosome Cellular component • mitochondrial inner membrane • ribosome • intracellular ribonucleoprotein complex • intracellular • mitochondrion • mitochondrial large ribosomal subunit Biological process • mitochondrial translational elongation • mitochondrial translational termination • translation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9553	66845
Ensembl	ENSG00000243147	ENSMUSG00000106918
UniProt	O75394	Q9CQP0
RefSeq (mRNA)	NM_145330 NM_004891	NM_025796
RefSeq (protein)	NP_004882.1 NP_663303.1	NP_080072.2
Location (UCSC)	Chr 2: 27.77 – 27.99 Mb	Chr 5: 31.6 – 31.66 Mb
PubMed search	[1]	[2]
Wikidata

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39S ribosomal protein L33, mitochondrial is a protein that in humans is encoded by the MRPL33 gene.^[3]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: MRPL33 mitochondrial ribosomal protein L33".

Further reading

• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.