Mean kinetic temperature

Mean kinetic temperature (MKT) is a simplified way of expressing the overall effect of temperature fluctuations during storage or transit of perishable goods. The MKT is widely used in the pharmaceutical industry.

The mean kinetic temperature can be expressed as:

${\displaystyle T_{K}={\cfrac {\frac {\Delta H}{R}}{-\ln \left({\frac {{t_{1}}e^{\left({\frac {-\Delta H}{RT_{1}}}\right)}+{t_{2}}e^{\left({\frac {-\Delta H}{RT_{2}}}\right)}+\cdots +{t_{n}}e^{\left({\frac {-\Delta H}{RT_{n}}}\right)}}{{t_{1}}+{t_{2}}+\cdots +{t_{n}}}}\right)}}}$

Where:

${\displaystyle T_{K}\,\!}$ is the mean kinetic temperature in kelvins

${\displaystyle \Delta H\,\!}$ is the activation energy (in kJ)

$R\,\!$ is the gas constant (in J mol⁻¹ K⁻¹)

$T_{1}\,\!$ to ${\displaystyle T_{n}\,\!}$ are the temperatures at each of the sample points in kelvins

${\displaystyle t_{1}\,\!}$ to ${\displaystyle t_{n}\,\!}$ are time intervals at each of the sample points

When the temperature readings are taken at the same interval (i.e., ${\displaystyle t_{1}\,\!}$ = ${\displaystyle t_{2}\,\!}$ = $\cdots$ = ${\displaystyle t_{n}\,\!}$), the above equation is reduced to:

${\displaystyle T_{K}={\cfrac {\frac {\Delta H}{R}}{-\ln \left({\frac {e^{\left({\frac {-\Delta H}{RT_{1}}}\right)}+e^{\left({\frac {-\Delta H}{RT_{2}}}\right)}+\cdots +e^{\left({\frac {-\Delta H}{RT_{n}}}\right)}}{n}}\right)}}}$

Where:

$n\,\!$ is the number of temperature sample points

External links

• Free Excel software for calculating MKT
• iStability MKT for calculation of MKT