Monongahela virus

Monongahela virus
Transmission electron micrograph of the Sin Nombre Hantavirus
Virus classification
Group: Group V ((-)ssRNA)
Order: Unassigned
Family: Bunyaviridae
Genus: Hantavirus
Type species
Hantaan virus
Species

Monongahela virus

Monongahela virus (MGLV) is a single-stranded, negative-sense RNA Hantavirus species of zoonotic origin that causes Hantavirus pulmonary syndrome.[1] The virus was first isolated from a White-footed mouse (Peromyscus leucopus), indigenous to Pennsylvania after two residents died from rapid onset of respiratory failure.

Discovery of virus

Monongahela virus was first detected in P. maniculatus nubiterrae (Cloudland deer mice) captured in the Monongahela National Forest in West Virginia in 1985.[2]

Transmission

This species of Hantavirus has not been shown to transfer from person to person. Transmission by aerosolized rodent excreta still remains the only known way the virus is transmitted to humans. In general, droplet and/or fomite transfer has not been shown in the hantaviruses in either the hemorrhagic or pulmonary forms.[3][4]

In both cases in Pennsylvania, the patients were living in rural areas and had recent exposure to rodent excreta prior to the onset of symptoms. Both patients developed rapid onset of respiratory distress and pulmonary edema, believed to be the result of cytokine storm, and both expired within 5 days of onset of symptoms.

See also

References

  1. ↑ Luther V. Rhodes, Cinnia Huang, Angela J. Sanchez, Stuart T. Nichol§, Sherif R. Zaki§, Thomas G. Ksiazek, J.G. Humphreys¶, James J. Freeman*, and Kenneth R. Knecht. Hantavirus Pulmonary Syndrome Associated with Monongahela Virus, Pennsylvania. Research. Volume 6, Number 6—December 2000.
  2. ↑ Song JW, Baek LJ, Nagle JW, Schlitter D, Yanagihara R (1996). "Genetic and phylogenetic analysis of hantaviral sequences amplified from archival tissues of deer mice (Peromyscus maniculatus nubiterrae) captured in the eastern United States". Arch Virol. 141: 959–67. doi:10.1007/bf01718170.
  3. ↑ Peters, C.J. (2006). "Emerging Infections: Lessons from the Viral Hemorrhagic Fevers". Transactions of the American Clinical and Climatological Association. Transactions of the American Clinical and Climatological Association. 117: 189–197. PMC 1500910Freely accessible. PMID 18528473.
  4. ↑ Crowley, J.; Crusberg, T. "Ebola and Marburg Virus Genomic Structure, Comparative and Molecular Biology". Dept. of Biology & Biotechnology, Worcester Polytechnic Institute.
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