Mucosal immunology

Mucosal immunology is the study of immune system responses that occur at mucosal membranes of the intestines, the urogenital tract and the respiratory system, i.e., surfaces that are in contact with the external environment.[1] In healthy states, the mucosal immune system provides protection against pathogens but maintains a tolerance towards non-harmful commensual microbes and benign environmental substances.[1] It provides three main functions: protecting the mucous membrane against infection; preventing the uptake of antigens, microorganisms, and other foreign materials; and moderating the organism's immune response.[2]

At birth, the neonate's mucosal immune system is relatively undeveloped, but the colonization of intestinal flora promotes its development.[3]

Because of its front-line status within the immune system, the mucosal immune system is being investigated for use in vaccines for various afflictions,[4] including AIDS[5][6][7][8] and allergies.[9]

References

  1. 1 2 "Mucosal immunology - Latest research and news | Nature". www.nature.com. Retrieved 2016-11-08.
  2. ↑ Reviews, C. T. I. (2016-10-17). Basic Immunology Updated Edition: Medicine, Allergology. Cram101 Textbook Reviews. ISBN 9781467235518.
  3. ↑ Torow, N.; Marsland, B. J.; Hornef, M. W.; Gollwitzer, E. S. (2016-09-21). "Neonatal mucosal immunology". Mucosal Immunology. doi:10.1038/mi.2016.81. ISSN 1935-3456. PMID 27649929.
  4. ↑ Mucosal Immunity and Vaccines, August 2003
  5. ↑ Pavot, V; Rochereau, N; Lawrence, P; Girard, MP; Genin, C; Verrier, B; Paul, S (31 July 2014). "Recent progress in HIV vaccines inducing mucosal immune responses.". AIDS (London, England). 28 (12): 1701–18. doi:10.1097/qad.0000000000000308. PMID 25009956.
  6. ↑ Bourinbaiar, Aldar S.; Metadilogkul, Orapun; Jirathitikal, Vichai (2003). "Mucosal AIDS Vaccines". Viral Immunology. 16 (4): 427–45. doi:10.1089/088282403771926274. PMID 14733732.
  7. ↑ Simerska, Pavla; Moyle, Peter M.; Olive, Colleen; Toth, Istvan (2009). "Oral Vaccine Delivery - New Strategies and Technologies". Current Drug Delivery. 6 (4): 347–58. doi:10.2174/156720109789000537. PMID 19534712.
  8. ↑ Silin, Dmytro S.; Lyubomska, Oksana V.; Jirathitikal, Vichai; Bourinbaiar, Aldar S. (2007). "Oral vaccination: where we are?". Expert Opinion on Drug Delivery. 4 (4): 323–40. doi:10.1517/17425247.4.4.323. PMID 17683247.
  9. ↑ Wild, C.; Wallner, M.; Hufnagl, K.; Fuchs, H.; Hoffmann-Sommergruber, K.; Breiteneder, H.; Scheiner, O.; Ferreira, F.; Wiedermann, U. (2007). "A recombinant allergen chimer as novel mucosal vaccine candidate for prevention of multi-sensitivities". Allergy. 62 (1): 33–41. doi:10.1111/j.1398-9995.2006.01245.x. PMID 17156339.

See also

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