Oncostatin M receptor

OSMR
Identifiers
Aliases	OSMR, OSMRB, PLCA1, IL-31R-beta, IL-31RB, oncostatin M receptor
External IDs	OMIM: 601743 MGI: 1330819 HomoloGene: 2972 GeneCards: OSMR
Gene ontology Molecular function • cytokine receptor activity • oncostatin-M receptor activity • growth factor binding Cellular component • integral component of membrane • oncostatin-M receptor complex • plasma membrane • apical plasma membrane • membrane Biological process • positive regulation of acute inflammatory response • response to cytokine • oncostatin-M-mediated signaling pathway • positive regulation of cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9180	18414
Ensembl	ENSG00000145623	ENSMUSG00000022146
UniProt	Q99650	O70458
RefSeq (mRNA)	NM_001168355 NM_003999 NM_001323504 NM_001323505 NM_001323506 NM_001323507	NM_011019 NM_001310469
RefSeq (protein)	NP_001161827.1 NP_003990.1 NP_001310433.1 NP_001310434.1 NP_001310435.1 NP_001310436.1	NP_001297398.1 NP_035149.2
Location (UCSC)	Chr 5: 38.85 – 38.95 Mb	Chr 15: 6.81 – 6.87 Mb
PubMed search	[1]	[2]
Wikidata

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Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor, is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene.^[3][4]

OSMR is a member of the type I cytokine receptor family. This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events.^[3]

Clinical significance

The oncostatin M receptor is associated with primary cutaneous amyloidosis.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: oncostatin M receptor".
4. Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS, Cosman D (December 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. 271 (51): 32635–43. doi:10.1074/jbc.271.51.32635. PMID 8999038.
5. Arita K, South AP, Hans-Filho G, et al. (January 2008). "Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis". Am. J. Hum. Genet. 82 (1): 73–80. doi:10.1016/j.ajhg.2007.09.002. PMC 2253984. PMID 18179886.

External links

• Oncostatin M Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.