PACSIN1

PACSIN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HAH, 3HAI, 3Q84, 3QNI
Identifiers
Aliases	PACSIN1, SDPI, protein kinase C and casein kinase substrate in neurons 1
External IDs	MGI: 1345181 HomoloGene: 22674 GeneCards: PACSIN1
Gene ontology Molecular function • cytoskeletal protein binding • protein binding • phospholipid binding • lipid binding Cellular component • cytoplasm • axon terminus • cytosol • endosome • cell projection • membrane • myelin sheath • plasma membrane • synapse • ruffle membrane • cell junction • perinuclear region of cytoplasm • neuron projection • cytoplasmic vesicle membrane • cytoplasmic vesicle • COPI-coated vesicle Biological process • regulation of endocytosis • negative regulation of endocytosis • protein localization to membrane • neuron projection morphogenesis • endocytosis • actin filament organization • neuron development • positive regulation of dendrite development • membrane tubulation • synaptic vesicle endocytosis • establishment of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29993	23969
Ensembl	ENSG00000124507	ENSMUSG00000040276
UniProt	Q9BY11	Q61644
RefSeq (mRNA)	NM_001199583 NM_020804	NM_001286743 NM_001286744 NM_011861 NM_178365
RefSeq (protein)	NP_001186512.1 NP_065855.1	NP_001273672.1 NP_001273673.1 NP_035991.1 NP_848142.1
Location (UCSC)	Chr 6: 34.47 – 34.54 Mb	Chr 17: 27.66 – 27.71 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Protein kinase C and casein kinase substrate in neurons protein 1 is an enzyme that in humans is encoded by the PACSIN1 gene.^[3][4]

Interactions

PACSIN1 has been shown to interact with:

• DNM1,^[5][6]
• Huntingtin^[7]
• PACSIN2,^[6][8] and
• PACSIN3.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M (Jan 2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family". Gene. 262 (1-2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684.
4. "Entrez Gene: PACSIN1 protein kinase C and casein kinase substrate in neurons 1".
5. Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, Mochizuki N (Sep 2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". The Journal of Biological Chemistry. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
6. Modregger J, Ritter B, Witter B, Paulsson M, Plomann M (Dec 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". Journal of Cell Science. 113 (24): 4511–21. PMID 11082044.
7. Modregger J, DiProspero NA, Charles V, Tagle DA, Plomann M (Oct 2002). "PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains". Human Molecular Genetics. 11 (21): 2547–58. doi:10.1093/hmg/11.21.2547. PMID 12354780.
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Qualmann B, Roos J, DiGregorio PJ, Kelly RB (Feb 1999). "Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein". Molecular Biology of the Cell. 10 (2): 501–13. doi:10.1091/mbc.10.2.501. PMC 25183. PMID 9950691.
• Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Feb 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Modregger J, Ritter B, Witter B, Paulsson M, Plomann M (Dec 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". Journal of Cell Science. 113 (24): 4511–21. PMID 11082044.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Zucconi A, Dente L, Santonico E, Castagnoli L, Cesareni G (Apr 2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1". Journal of Molecular Biology. 307 (5): 1329–39. doi:10.1006/jmbi.2001.4572. PMID 11292345.
• Wasiak S, Quinn CC, Ritter B, de Heuvel E, Baranes D, Plomann M, McPherson PS (Jul 2001). "The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton". The Journal of Biological Chemistry. 276 (28): 26622–8. doi:10.1074/jbc.M100591200. PMID 11352907.
• Modregger J, DiProspero NA, Charles V, Tagle DA, Plomann M (Oct 2002). "PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains". Human Molecular Genetics. 11 (21): 2547–58. doi:10.1093/hmg/11.21.2547. PMID 12354780.
• Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, Mochizuki N (Sep 2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". The Journal of Biological Chemistry. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Cuajungco MP, Grimm C, Oshima K, D'hoedt D, Nilius B, Mensenkamp AR, Bindels RJ, Plomann M, Heller S (Jul 2006). "PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4". The Journal of Biological Chemistry. 281 (27): 18753–62. doi:10.1074/jbc.M602452200. PMID 16627472.