PCDH8

PCDH8
Identifiers
Aliases	PCDH8, ARCADLIN, PAPC, protocadherin 8
External IDs	MGI: 1306800 HomoloGene: 1943 GeneCards: PCDH8
Gene ontology Molecular function • calcium ion binding Cellular component • cell projection • cell junction • postsynaptic membrane • plasma membrane • membrane • presynaptic membrane • integral component of membrane • synapse • dendrite • integral component of plasma membrane Biological process • morphogenesis of embryonic epithelium • somitogenesis • chemical synaptic transmission • homophilic cell adhesion via plasma membrane adhesion molecules • cell-cell signaling • cell adhesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5100	18530
Ensembl	ENSG00000136099	ENSMUSG00000036422
UniProt	O95206	Q7TSK3
RefSeq (mRNA)	NM_032949 NM_002590	NM_001042726 NM_021543
RefSeq (protein)	NP_002581.2 NP_116567.1	NP_001036191.1 NP_067518.2
Location (UCSC)	Chr 13: 52.84 – 52.85 Mb	Chr 14: 79.77 – 79.77 Mb
PubMed search	[1]	[2]
Wikidata

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Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.^[3][4][5]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Strehl S, Glatt K, Liu QM, Glatt H, Lalande M (Dec 1998). "Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14". Genomics. 53 (1): 81–9. doi:10.1006/geno.1998.5467. PMID 9787079.
4. Strehl S, LaSalle JM, Lalande M (Oct 1997). "High-resolution analysis of DNA replication domain organization across an R/G-band boundary". Mol Cell Biol. 17 (10): 6157–66. PMC 232466. PMID 9315676.
5. "Entrez Gene: PCDH8 protocadherin 8".

Further reading

• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752.
• Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
• Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929.
• Yamagata K, Andreasson KI, Sugiura H, et al. (1999). "Arcadlin is a neural activity-regulated cadherin involved in long term potentiation". J. Biol. Chem. 274 (27): 19473–1979. doi:10.1074/jbc.274.27.19473. PMID 10383464.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
• Wu Q, Zhang T, Cheng JF, et al. (2001). "Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters". Genome Res. 11 (3): 389–404. doi:10.1101/gr.167301. PMC 311048. PMID 11230163.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bray NJ, Kirov G, Owen RJ, et al. (2003). "Screening the human protocadherin 8 (PCDH8) gene in schizophrenia". Genes, Brain and Behavior. 1 (3): 187–91. doi:10.1034/j.1601-183X.2002.10307.x. PMID 12884975.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.