POLR3C

POLR3C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XUB, 2XV4, 5AFQ
Identifiers
Aliases	POLR3C, RPC3, RPC62, polymerase (RNA) III subunit C
External IDs	MGI: 1921664 HomoloGene: 38185 GeneCards: POLR3C
Gene ontology Molecular function • DNA-directed 5'-3' RNA polymerase activity • DNA binding • protein binding • RNA polymerase III activity Cellular component • DNA-directed RNA polymerase III complex • cytosol • nucleus • nucleoplasm Biological process • positive regulation of interferon-beta production • regulation of transcription from RNA polymerase III promoter • defense response to virus • positive regulation of type I interferon production • transcription, DNA-templated • positive regulation of innate immune response • immune system process • innate immune response • transcription from RNA polymerase III promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10623	74414
Ensembl	ENSG00000186141	ENSMUSG00000028099
UniProt	Q9BUI4	Q9D483
RefSeq (mRNA)	NM_001303456 NM_006468	NM_028925
RefSeq (protein)	NP_001290385.1 NP_006459.3	NP_083201.1
Location (UCSC)	Chr 1: 145.82 – 145.84 Mb	Chr 3: 96.71 – 96.73 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene.^[3][4][5]

Interactions

POLR3C has been shown to interact with GTF3C4.^[6][7]

Related gene problems

• TAR syndrome^[8]
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Wang Z, Roeder RG (Jun 1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes Dev. 11 (10): 1315–26. doi:10.1101/gad.11.10.1315. PMID 9171375.
4. Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Oct 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits". Mol Cell Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
5. "Entrez Gene: POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)".
6. Hsieh, Y J; Wang Z; Kovelman R; Roeder R G (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. UNITED STATES. 19 (7): 4944–52. ISSN 0270-7306. PMC 84305. PMID 10373544.
7. Hsieh, Y J; Kundu T K; Wang Z; Kovelman R; Roeder R G (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. UNITED STATES. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. ISSN 0270-7306. PMC 84812. PMID 10523658.
8. Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

Further reading

• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC.". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hsieh YJ, Wang Z, Kovelman R, Roeder RG (1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III.". Mol. Cell. Biol. 19 (7): 4944–52. PMC 84305. PMID 10373544.
• Hsieh YJ, Kundu TK, Wang Z, et al. (1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity.". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
• Kuwana M, Kimura K, Kawakami Y (2002). "Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay.". Arthritis Rheum. 46 (10): 2742–7. doi:10.1002/art.10521. PMID 12384934.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.