POLR3D
| POLR3D | ||||||
|---|---|---|---|---|---|---|
| Identifiers | ||||||
| Aliases | POLR3D, BN51T, RPC4, RPC53, TSBN51, polymerase (RNA) III subunit D | |||||
| External IDs | MGI: 1914315 HomoloGene: 1303 GeneCards: POLR3D | |||||
| RNA expression pattern | ||||||
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| More reference expression data | ||||||
| Orthologs | ||||||
| Species | Human | Mouse | ||||
| Entrez | ||||||
| Ensembl | ||||||
| UniProt | ||||||
| RefSeq (mRNA) | ||||||
| RefSeq (protein) | ||||||
| Location (UCSC) | Chr 8: 22.25 – 22.25 Mb | Chr 14: 70.44 – 70.44 Mb | ||||
| PubMed search | [1] | [2] | ||||
| Wikidata | ||||||
| View/Edit Human | View/Edit Mouse |
DNA-directed RNA polymerase III subunit RPC4 is an enzyme that in humans is encoded by the POLR3D gene.[3][4][5]
This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures.[5]
Interactions
POLR3D has been shown to interact with POLR3E.[3]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- 1 2 Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Oct 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits". Mol Cell Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740
. PMID 12391170. - ↑ Chong SS, Hu P, Hernandez N (Jun 2001). "Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex". J Biol Chem. 276 (23): 20727–34. doi:10.1074/jbc.M100088200. PMID 11279001.
- 1 2 "Entrez Gene: POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa".
Further reading
- Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC.". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
- Greco A, Ittmann M, Barletta C, et al. (1989). "Chromosomal localization of human genes required for G1 progression in mammalian cells.". Genomics. 4 (3): 240–5. doi:10.1016/0888-7543(89)90326-1. PMID 2714790.
- Ittmann M, Greco A, Basilico C (1988). "Isolation of the human gene that complements a temperature-sensitive cell cycle mutation in BHK cells.". Mol. Cell. Biol. 7 (10): 3386–93. PMC 367988. PMID 3683386.
- Jackson AJ, Ittmann M, Pugh BF (1995). "The BN51 protein is a polymerase (Pol)-specific subunit of RNA Pol III which reveals a link between Pol III transcription and pre-rRNA processing.". Mol. Cell. Biol. 15 (1): 94–101. PMC 231913. PMID 7799973.
- Ittmann MM (1994). "Cell cycle control of the BN51 cell cycle gene which encodes a subunit of RNA polymerase III.". Cell Growth Differ. 5 (7): 783–8. PMID 7947392.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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