PPIH

PPIH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MZW, 1QOI
Identifiers
Aliases	PPIH, CYP-20, CYPH, SnuCyp-20, USA-CYP, peptidylprolyl isomerase H
External IDs	MGI: 106499 HomoloGene: 38172 GeneCards: PPIH
Gene ontology Molecular function • cyclosporin A binding • ribonucleoprotein complex binding • isomerase activity • protein binding • peptidyl-prolyl cis-trans isomerase activity Cellular component • cytoplasm • nuclear speck • U4/U6 x U5 tri-snRNP complex • spliceosomal complex • nucleus • nucleoplasm • U4/U6 snRNP Biological process • mRNA splicing, via spliceosome • mRNA processing • positive regulation of viral genome replication • protein folding • protein peptidyl-prolyl isomerization • protein complex assembly • RNA splicing Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10465	66101
Ensembl	ENSG00000171960	ENSMUSG00000060288
UniProt	O43447	Q9D868
RefSeq (mRNA)	NM_006347	NM_001110129 NM_001110130 NM_028677
RefSeq (protein)	NP_006338.1	NP_001103599.1 NP_001103600.1 NP_082953.1
Location (UCSC)	Chr 1: 42.66 – 42.68 Mb	Chr 4: 119.3 – 119.32 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.^[3][4][5]

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs". RNA. 3 (12): 1374–87. PMC 1369579. PMID 9404889.
4. Teigelkamp S, Achsel T, Mundt C, Gothel SF, Cronshagen U, Lane WS, Marahiel M, Luhrmann R (May 1998). "The 20kD protein of human U4/U6.U5 tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins". RNA. 4 (2): 127–41. PMC 1369602. PMID 9570313.
5. "Entrez Gene: PPIH peptidylprolyl isomerase H (cyclophilin H)".

Further reading

• Reidt U, Reuter K, Achsel T, et al. (2000). "Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin". J. Biol. Chem. 275 (11): 7439–42. doi:10.1074/jbc.275.11.7439. PMID 10713041.
• Horowitz DS, Lee EJ, Mabon SA, Misteli T (2002). "A cyclophilin functions in pre-mRNA splicing". EMBO J. 21 (3): 470–80. doi:10.1093/emboj/21.3.470. PMC 125845. PMID 11823439.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Reidt U, Wahl MC, Fasshauer D, et al. (2003). "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide". J. Mol. Biol. 331 (1): 45–56. doi:10.1016/S0022-2836(03)00684-3. PMID 12875835.
• Ingelfinger D, Göthel SF, Marahiel MA, et al. (2004). "Two protein–protein interaction sites on the spliceosome-associated human cyclophilin CypH". Nucleic Acids Res. 31 (16): 4791–6. doi:10.1093/nar/gkg660. PMC 169899. PMID 12907720.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.