PPP1R9A

PPP1R9A
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1WF8
Identifiers
Aliases	PPP1R9A, NRB1, NRBI, Neurabin-I, protein phosphatase 1 regulatory subunit 9A
External IDs	MGI: 2442401 HomoloGene: 14247 GeneCards: PPP1R9A
Gene ontology Molecular function • protein homodimerization activity • ion channel binding • protein domain specific binding • protein complex binding • protein phosphatase 1 binding • actin filament binding • protein C-terminus binding • protein binding • GTPase binding • actin binding • protein kinase binding Cellular component • cytoplasm • dendritic spine neck • cytosol • postsynaptic density • filopodium • growth cone • neuromuscular junction • dendritic spine • synapse • growth cone lamellipodium • cell junction • neuronal cell body • dendrite • cortical actin cytoskeleton • actin cytoskeleton • neuron projection • cytoskeleton • lamellipodium Biological process • regulation of filopodium assembly • cell differentiation • regulation of synapse structural plasticity • actin filament organization • regulation of synapse assembly • aging • cellular response to toxic substance • neuron development • positive regulation of dendritic spine development • nervous system development • multicellular organism development • regulation of actin filament polymerization • excitatory postsynaptic potential • negative regulation of long-term synaptic potentiation • negative regulation of spontaneous neurotransmitter secretion • positive regulation of long term synaptic depression • positive regulation of neuron projection development • negative regulation of stress fiber assembly • neuron projection development • regulation of dendritic spine morphogenesis • calcium-mediated signaling • positive regulation of protein kinase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55607	243725
Ensembl	ENSG00000158528	ENSMUSG00000032827
UniProt	Q9ULJ8	n/a
RefSeq (mRNA)	NM_001166160 NM_001166161 NM_001166162 NM_001166163 NM_017650	NM_181595
RefSeq (protein)	NP_001159632.1 NP_001159633.1 NP_001159634.1 NP_001159635.1 NP_060120.2 NP_001159635.1	n/a
Location (UCSC)	Chr 7: 94.91 – 95.3 Mb	Chr 6: 4.9 – 5.17 Mb
PubMed search	[1]	[2]
Wikidata

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Neurabin-1 is a protein that in humans is encoded by the PPP1R9A gene.^[3][4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
4. "Entrez Gene: PPP1R9A protein phosphatase 1, regulatory (inhibitor) subunit 9A".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Nakanishi H, Obaishi H, Satoh A, et al. (1997). "Neurabin: A Novel Neural Tissue–specific Actin Filament–binding Protein Involved in Neurite Formation". J. Cell Biol. 139 (4): 951–61. doi:10.1083/jcb.139.4.951. PMC 2139968. PMID 9362513.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• McAvoy T, Allen PB, Obaishi H, et al. (1999). "Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation". Biochemistry. 38 (39): 12943–9. doi:10.1021/bi991227d. PMID 10504266.
• Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. doi:10.1074/jbc.274.42.30080. PMID 10514494.
• Oliver CJ, Terry-Lorenzo RT, Elliott E, et al. (2002). "Targeting Protein Phosphatase 1 (PP1) to the Actin Cytoskeleton: the Neurabin I/PP1 Complex Regulates Cell Morphology". Mol. Cell. Biol. 22 (13): 4690–701. doi:10.1128/MCB.22.13.4690-4701.2002. PMC 133892. PMID 12052877.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.