Patterson syndrome

Patterson syndrome
Classification and external resources
OMIM 169170

Patterson syndrome, also called pseudoleprechaunism, is an extremely rare syndrome, first mistaken as Donohue Syndrome (also known as Leprechaunism).

It is named for Dr. Joseph Hanan Patterson.[1] It was described by Patterson and Watkins in 1962.[2]

The pathogenesis and etiology of the Patterson syndrome was unknown until 1981.[3]

Characteristics

Patterson syndrome is characterized by the patient's having an unusual facial look, similar to that caused by Leprechaunism. It primarily affects the connective tissue and the neuroendocrine system, giving rise to bronzed hyperpigmentation, cutis laxa of the hands and feet, bodily disproportion, severe mental retardation, and major bony deformities. Radiographs reveal a characteristic generalised skeletal dysplasia.

It comprises endocrine abnormality, hyperadrenocorticism, cushingoid features, and diabetes mellitus. One other case has shown premature adrenarche.

References

  1. ↑ Zach Samson (July 1, 2006). "Dr. Patterson, influential past president of AAP Georgia Chapter". AAP News. 27 (7): 39. Retrieved 2008-03-24.
  2. ↑ PATTERSON JH, WATKINS WL (1962). "Leprechaunism in a male infant". J. Pediatr. 60 (5): 730–9. doi:10.1016/S0022-3476(62)80100-0. PMID 14484402.
  3. ↑ David TJ, Webb BW, Gordon IR (1981). "The Patterson syndrome, leprechaunism, and pseudoleprechaunism". J. Med. Genet. 18 (4): 294–8. doi:10.1136/jmg.18.4.294. PMC 1048735Freely accessible. PMID 7277424.


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