Pemphigoid

Pemphigoid
Classification and external resources
ICD-10 L12
ICD-9-CM 694.5
DiseasesDB 9760
Patient UK Pemphigoid
MeSH D010391

Pemphigoid is a group of rare autoimmune blistering skin diseases. As its name indicates, pemphigoid is similar in general appearance to pemphigus,[1] but, unlike pemphigus, pemphigoid does not feature acantholysis, a loss of connections between skin cells.[2]

Pemphigoid is more common than pemphigus, and is slightly more common in women than in men. It is also more common in people over 60 years of age than it is in younger people.

Classification

IgG

The forms of pemphigoid are considered to be connective tissue autoimmune skin diseases. There are several types:

Bullous and Cicatricial pemphigoids usually affect persons who are over age 60.[3][4] Gestational pemphigoid occurs during pregnancy,[5] typically in the second or third trimester, and/or immediately following pregnancy.

IgA

Pemphigoid is usually considered to be mediated by IgG, but IgA-mediated forms have also been described.[6]

IgA-mediated immunobullous diseases can often be difficult to treat even with usually effective medications such as rituximab.[7]

See also

References

  1. ↑ "pemphigoid" at Dorland's Medical Dictionary
  2. ↑ Pemphigoid at the US National Library of Medicine Medical Subject Headings (MeSH)
  3. ↑ Cicatricial Pemphigoid at eMedicine
  4. ↑ Bullous Pemphigoid at eMedicine
  5. ↑ Pemphigoid Gestationis at eMedicine
  6. ↑ Thomas T. Provost; John A. Flynn (2001). Cutaneous medicine: cutaneous manifestations of systemic disease. PMPH-USA. pp. 209–. ISBN 978-1-55009-100-7. Retrieved 25 June 2010.
  7. ↑ He Y, Shimoda M, Ono Y, Villalobos IB, Mitra A, Konia T, Grando SA, Zone JJ, Maverakis E (2015). "Persistence of Autoreactive IgA-Secreting B Cells Despite Multiple Immunosuppressive Medications Including Rituximab". JAMA Dermatol. 151 (6): 646–50. doi:10.1001/jamadermatol.2015.59. PMID 25901938.
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