Peripolesis

Peripolesis is the process in which a cell attaches itself to another cell. This is differentiated from emperipolesis, which is when one cell is engulfed by another.

Peripolesis is thought to be a physiological mechanism involved in regulating some processes of immune response. It was observed between lymphocytes and macrophages following skin grafts between subjects, and after immune challenge with antigens.[1] Peripolesis was also observed in lung alveoli, where the peripolesed macrophages were not injured, but the cell membrane did appear to be temporarily altered.[2] In patients with active sarcoidosis, which is characterized by lymphocyte-marophage cooperaction, lymphocyte peripolesis appeared to occur in clusters and could last for minutes to hours. The lymphocytes could be seen moving around a macrophage while maintaining contact.[3]

References

  1. ↑ Sharp, J. A.; Burwell, R. G. (1960-11-05). "Interaction ('Peripolesis') of Macrophages and Lymphocytes after Skin Homografting or Challenge with Soluble Antigens". Nature. 188 (4749): 474–475. doi:10.1038/188474a0.
  2. ↑ Lyons DJ, Gautam A, Clark J, Harries MG, Mitchell EB, Milledge JS, Balfour BM (Jan 1992). "Lymphocyte macrophage interactions: peripolesis of human alveolar macrophages". European Respiratory Journal. PMID 1577151.
  3. ↑ van Maarsseveen, Ton C.; de Groot, Jan; Stam, Jaap; van Diest, Paul J. (1993-05-01). "Peripolesis in Alveolar Sarcoidosis". American Review of Respiratory Disease. 147 (5): 1259–1263. doi:10.1164/ajrccm/147.5.1259. ISSN 0003-0805.
This article is issued from Wikipedia - version of the 11/8/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.