Polyphenolic protein

This article is about mussel and related proteins carrying oxidative PTMs associated with bioadhesion. It is not to be confused with polyphenols or phenol polymers.

The small family of proteins that are sometimes referred to as polyphenolic proteins are produced by some marine invertebrates like the blue mussel, Mytilus edulis[1] by some algae', and by the polychaete Phragmatopoma californica.[2] These proteins contain a high level of a post-translationally modified—oxidized—form of tyrosine, L-3,4-dihydroxyphenylalanine (levodopa, L-DOPA)[2] as well as the disulfide (oxidized) form of cysteine (cystine).[1] In the zebra mussel (Dreissena polymorpha), two such proteins, Dpfp-1 and Dpfp-2, localize in the juncture between byssus threads and adhesive plaque.[3] The presence of these proteins appear, generally, to contribute to stiffening of the materials functioning as bioadhesives.[4] The presence of the dihydroxyphenylalanine-moiety arises from action of a tyrosine hydroxylase-type of enzyme; in vitro, it has been shown that the proteins can be cross-linked (polymerized) using a mushroom tyrosinase.[5]

References

  1. 1 2 Rzepecki, Leszek M.; Hansen, Karolyn M.; Waite, J. Herbert (August 1992). "Characterization of a Cystine-Rich Polyphenolic Protein Family from the Blue Mussel Mytilus edulis L.". Biological Bulletin. 183 (1): 123–37. doi:10.2307/1542413. JSTOR 1542413.
  2. 1 2 Jensen, Rebecca A.; Morse, Daniel E. (1988). "The bioadhesive of Phragmatopoma californica tubes: a silk-like cement containing L-DOPA". Journal of Comparative Physiology B. 158 (3): 317–24. doi:10.1007/BF00695330.
  3. ↑ Rzepecki, LM; Waite, JH (1993). "The byssus of the zebra mussel, Dreissena polymorpha. II: Structure and polymorphism of byssal polyphenolic protein families". Molecular marine biology and biotechnology. 2 (5): 267–79. PMID 8180628.
  4. ↑ Rzepecki, LM; Chin, SS; Waite, JH; Lavin, MF (1991). "Molecular diversity of marine glues: Polyphenolic proteins from five mussel species". Molecular marine biology and biotechnology. 1 (1): 78–88. PMID 1845474.
  5. ↑ Burzio, Luis A; Burzio, Veronica A; Pardo, Joel; Burzio, Luis O (2000). "In vitro polymerization of mussel polyphenolic proteins catalyzed by mushroom tyrosinase". Comparative Biochemistry and Physiology B. 126 (3): 383–9. doi:10.1016/S0305-0491(00)00188-7.

adhesive_protein,_mussel at the US National Library of Medicine Medical Subject Headings (MeSH)


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