Polysialic acid

Polysialic acid is an unusual posttranslational modification that occurs on neural cell adhesion molecules (NCAM). Polysialic acid is considerably anionic. This strong negative charge gives this modification the ability to change the protein's surface charge and binding ability. In the synapse, polysialation of NCAM prevents its ability to bind to NCAM's on the adjacent membrane.[1]

See also

References

  1. ↑ Dityatev, Alexander and Alaa El-Husseini, ed. (2006). "ch 6". Molecular Mechanisms of Synaptogenesis. New York, NY: Springer.


This article is issued from Wikipedia - version of the 7/11/2014. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.