Proembryo

Proembryo, or pro-embryo, is a botanical term that has been used for centuries, to denote the series of cells that are formed after fertilization within the ovule of a flowering plant, before formation of the embryo.[1]

More recently, this same term has been given a more extensive meaning, with reference to human egg cells (ova) that have been fertilized but not yet implanted into a uterus. This more recent meaning is synonymous with "preembryo" or "pre-embryo,"[2] and corresponds to stages with more accepted terms zygote and blastocyst.

Preembryo in context of human development

A preembryo is a human conceptus at least between fertilization and implantation, and is known too as a proembryo.[3] A conceptus between fertilization and implantation is also frequently classified as an embryo.[3]

Even after implantation begins, a preembryo (and proembryo) may exist up until formation of the primitive streak.[4] Implantation begins at about six days after fertilization, and lasts for about a week, during which time formation of the primitive streak occurs.[5]

Use of the terms preembryo and proembryo, in the context of human development, has drawn criticism from opponents of embryo research, and from scientists who have considered this categorization invalid or unnecessary.[2][6][7] One rationale that has been advanced for distinguishing an early fertilized human conceptus from an embryo is that there is a potential for the conceptus to split into identical twins prior to implantation, and so (the argument goes) the conceptus cannot be regarded before implantation as a single human being. However, the conceptus before implantation exhibits self-actuated activity, which has led to the assertion that it is an embryo.[8] Further, identical twinning is an instance of asexual reproduction whereby a conceptus, without ceasing to be what it is (a new human being), provides a cell or cells as a new conceptus, entirely separated or partially separated (a 'siamese' twin) from the original conceptus, but in any event self-actuated in its development from the moment that the act of asexual reproduction (twinning) is complete. By this asexual reproduction, the parents of the original conceptus in effect become grandparents to the identical twin so conceived.

In the United States, a report by the National Institutes of Health stated that a conceptus could be both a pre-implantation embryo and a pre-embryo at the same time.[9] However, Ann Kiessling (a leader in stem cell research) has written that those categories are inaccurate.[10]

Ontological status

The ontological status of the proembryo, embryo, and fetus

The illustration shows the ontological status of the preembryo, embryo, and fetus:

  • (o) indicates the (natural &) standard reproductive and embryogenic pathway
  • (mz) indicates all the possible pathways for a monozygotic twin (see Scott, 2002, Hall, 2003, for a review on monozygotic twinning)
  • (/c) indicates a clone created by either SCNT or ANT (See Hurlbut, 2005, and section III. Pluripotent Stem Cells Derived from Biological Artifacts in the PCBE's Report on alternative sources of stem cells for a review of ANT))
  • (ch) indicates all the possible pathways for a chimeric individual (see Charles E. Boklage, 2006, for a review on chimerism and twinning)
  • (dz) indicates the pathway of a dizygotic twin
  • (en) indicates an enucleated oocyte
  • (m) indicates a hydatidiform mole
  • (cm) indicates a complete hydatidiform mole
  • (pm) indicates a partial hydatidiform mole, and
  • (p) indicates parthenogenesis.
  • (O) indicates an oocyte,
  • (Z) indicates a zygote,
  • (M) indicates a morula,
  • (B) indicates a blastocyst,
  • (E) indicates an embryo,
  • (F) indicates a fetus,
  • (I) indicates a live born individual person.
  • (PM) indicates a partial hydatidiform mole,
  • (CM) indicates a complete hydatidiform mole,
  • (T) indicates a teratoma.

The colors represent the maternal and paternal genetic contributions.

See also

Footnotes

  1. ↑ Webster's Revised Unabridged Dictionary, (1913).
  2. 1 2 Spallone, Patricia. “Bad Conscience and Collective Unconscious: Science, Discourse and Reproductive Technology” in Rosenbeck, Bente et al. Forplantning, køn og teknologi, pages 131-132 (Museum Tusculanum Press 1995).
  3. 1 2 Dyson, Anthony and Harris, John. Ethics and Biotechnology, page 94 (Routledge 1994).
  4. ↑ Pickering, Neil and Evans, Donald. Creating the Child, page 39 (Martinus Nijhoff Publishers 1996).
  5. ↑ Steinbock, Bonnie. “Life Before Birth,” pages 50 and 214-215 (Oxford University Press 1992).
  6. ↑ Mulkay, Michael. The Embryo Research Debate, page 31 (Cambridge University Press 1997).
  7. ↑ Braude, Peter. “Preimplantation Genetic Diagnosis and Embryo Research-Human Developmental Biology in Clinical Practice,” International Journal of Developmental Biology, volume 45, page 607 (2001).
  8. ↑ Ashley, Benedict and O’Rourke, Kevin. Ethics of Health Care: An Introductory Textbook, page 127 (Georgetown University Press 2002).
  9. ↑ Report of the Human Embryo Research Panel of the National Institutes of Health (1994).
  10. ↑ Kiessling, Ann. What is an Embryo?” Connecticut Law Review 36 (4): 1051–93.
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