Prostaglandin-F synthase

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP⁺ 11-oxidoreductase. Other names in common use include prostaglandin-D₂ 11-reductase, reductase, 15-hydroxy-11-oxoprostaglandin, PGD₂ 11-ketoreductase, PGF_2α synthetase, prostaglandin 11-ketoreductase, prostaglandin D₂-ketoreductase, prostaglandin F synthase, prostaglandin F synthetase, synthetase, prostaglandin F_2α, prostaglandin-D₂ 11-reductase, PGF synthetase, NADPH-dependent prostaglandin D₂ 11-keto reductase, and prostaglandin 11-keto reductase. This enzyme participates in arachidonic acid metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1RY0, 1RY8, 1VBJ, 1XF0, 1ZQ5, 2F38, and 2FGB.

References

Reingold DF, Kawasaki A, Needleman P (1981). "A novel prostaglandin 11-keto reductase found in rabbit liver". Biochim. Biophys. Acta. 659 (1): 179–88. doi:10.1016/0005-2744(81)90282-5. PMID 7248318.
Watanabe K, Shimizu T, Hayaishi O (1981). "Enzymatic conversion of prostaglandin-D₂ to prostaglandin-F_2α in the rat lung". Biochem. Int. 2: 603–610.
Watanabe K, Yoshida R, Shimizu T, Hayaishi O (1985). "Enzymatic formation of prostaglandin F_2α from prostaglandin H₂ and D₂. Purification and properties of prostaglandin F synthetase from bovine lung". J. Biol. Chem. 260 (11): 7035–41. PMID 3858278.
Wong PY (1981). "Purification and partial characterization of prostaglandin D₂ 11-keto reductase in rabbit liver". Biochim. Biophys. Acta. 659 (1): 169–78. doi:10.1016/0005-2744(81)90281-3. PMID 7248317.
Wong PY (1982). "Purification of PGD₂ 11-ketoreductase from rabbit liver". Methods Enzymol. 86: 117–25. doi:10.1016/0076-6879(82)86179-X. PMID 7132748.

Oxidoreductases: alcohol oxidoreductases (EC 1.1)

1.1.1: NAD/NADP acceptor	3-hydroxyacyl-CoA dehydrogenase 3-hydroxybutyryl-CoA dehydrogenase Alcohol dehydrogenase Aldo-keto reductase 1A1 1B1 1B10 1C1 1C3 1C4 7A2 Aldose reductase Beta-Ketoacyl ACP reductase Carbohydrate dehydrogenases Carnitine dehydrogenase D-malate dehydrogenase (decarboxylating) DXP reductoisomerase Glucose-6-phosphate dehydrogenase Glycerol-3-phosphate dehydrogenase HMG-CoA reductase IMP dehydrogenase Isocitrate dehydrogenase Lactate dehydrogenase L-threonine dehydrogenase L-xylulose reductase Malate dehydrogenase Malate dehydrogenase (decarboxylating) Malate dehydrogenase (NADP+) Malate dehydrogenase (oxaloacetate-decarboxylating) Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) Phosphogluconate dehydrogenase Sorbitol dehydrogenase Hydroxysteroid dehydrogenase: 3 Beta 3-beta-HSD NSDHL 11 Beta HSD11B1 HSD11B2 17 Beta

1.1.2: cytochrome acceptor	D-lactate dehydrogenase (cytochrome) D-lactate dehydrogenase (cytochrome c-553) Mannitol dehydrogenase (cytochrome)

1.1.3: oxygen acceptor	Glucose oxidase L-gulonolactone oxidase Xanthine oxidase

1.1.4: disulfide as acceptor	Vitamin K epoxide reductase Vitamin-K-epoxide reductase (warfarin-insensitive)

1.1.5: quinone/similar acceptor	Malate dehydrogenase (quinone) Quinoprotein glucose dehydrogenase

1.1.99: other acceptors	Choline dehydrogenase L2HGDH

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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