Pseudotropine acyltransferase

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Pseudotropine acyltransferase (EC 2.3.1.186, pseudotropine:acyl-CoA transferase, tigloyl-CoA:pseudotropine acyltransferase, acetyl-CoA:pseudotropine acyltransferase, pseudotropine acetyltransferase, pseudotropine tigloyltransferase, PAT) is an enzyme with systematic name acyl-CoA:pseudotropine O-acyltransferase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

acyl-CoA + pseudotropine

\rightleftharpoons

CoA + O-acylpseudotropine

This enzyme exhibits absolute specificity for the exo/3beta configuration found in pseudotropine as tropine (tropan-3alpha-ol).

References

↑ Rabot, S.; Peerless, A.C.J.; Robins, R.J. (1995). "Tigloyl-CoA:pseudotropine acyltransferase — an enzyme of tropane alkaloid biosynthesis". Phytochemistry. 39: 315–322. doi:10.1016/0031-9422(94)00907-b.
↑ Robins, R.J.; Bachmann, P.; Robinson, T.; Rhodes, M.J.; Yamada, Y. (1991). "The formation of 3α- and 3β-acetoxytropanes by Datura stramonium transformed root cultures involves two acetyl-CoA-dependent acyltransferases". FEBS Lett. 292: 293–297. doi:10.1016/0014-5793(91)80887-9. PMID 1959620.
↑ Robins, R.J.; Bachmann,P.; Peerless, A.C.J.; Rabot, S. (1994). "Esterification reactions in the biosynthesis of tropane alkaloids in transformed root cultures". Plant Cell, Tissue Organ Cult. 38: 241–247. doi:10.1007/bf00033883.
↑ Boswell, H.D.; Dräger, B.; McLauchlan, W.R.; Portsteffen, A.; Robins, D.J.; Robins, R.J.; Walton, N.J. (1999). "Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura". Phytochemistry. 52: 871–878. doi:10.1016/S0031-9422(99)00293-9. PMID 10626376.

External links

Pseudotropine acyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: acyltransferases (EC 2.3)

2.3.1: other than amino-acyl groups	acetyltransferases: Acetyl-Coenzyme A acetyltransferase N-Acetylglutamate synthase Choline acetyltransferase Dihydrolipoyl transacetylase Acetyl-CoA C-acyltransferase Beta-galactoside transacetylase Chloramphenicol acetyltransferase N-acetyltransferase Serotonin N-acetyl transferase HGSNAT ARD1A Histone acetyltransferase P300/CBP NAT2 palmitoyltransferases: Carnitine O-palmitoyltransferase CPT1 CPT2 Serine C-palmitoyltransferase SPTLC1 SPTLC2 other: Acyltransferase like 2 Aminolevulinic acid synthase Beta-ketoacyl-ACP synthase Glyceronephosphate O-acyltransferase Lecithin—cholesterol acyltransferase Glycerol-3-phosphate O-acyltransferase 1-acylglycerol-3-phosphate O-acyltransferase 2-acylglycerol-3-phosphate O-acyltransferase ABHD5

2.3.2: Aminoacyltransferases	Gamma-glutamyl transpeptidase Peptidyl transferase Transglutaminase Tissue transglutaminase Keratinocyte transglutaminase Factor XIII

2.3.3: converted into alkyl on transfer	Citrate synthase ATP citrate lyase HMG-CoA synthase Malate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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