QRFP

QRFP
Identifiers
Aliases	QRFP, 26RFa, P518, pyroglutamylated RFamide peptide
External IDs	MGI: 3630329 HomoloGene: 52341 GeneCards: QRFP
Gene ontology Molecular function • orexigenic neuropeptide QRFP receptor binding • neuropeptide hormone activity Cellular component • extracellular region • cellular component Biological process • grooming behavior • positive regulation of blood pressure • neuropeptide signaling pathway • regulation of feeding behavior • locomotory behavior Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	347148	227717
Ensembl	ENSG00000188710	ENSMUSG00000043102
UniProt	P83859	Q8CE23
RefSeq (mRNA)	NM_198180	NM_183424
RefSeq (protein)	NP_937823.1	NP_906269.1
Location (UCSC)	Chr 9: 130.89 – 130.9 Mb	Chr 2: 31.81 – 31.81 Mb
PubMed search	[1]	[2]
Wikidata

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RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein.^[3]

The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.^[4] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: P518 RF(Arg-Phe)amide family 26 amino acid peptide".
4. Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.
5. Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.

External links

• "Peptide P518 Receptor". IUPHAR/BPS Guide to PHARMACOLOGY.

Further reading

• Bruzzone F, Lectez B, Tollemer H, et al. (2007). "Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord.". J. Neurochem. 99 (2): 616–27. doi:10.1111/j.1471-4159.2006.04090.x. PMID 16899066.
• Chartrel N, Bruzzone F, Dujardin C, et al. (2006). "Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals". Ann. N. Y. Acad. Sci. 1040: 80–3. Bibcode:2005NYASA1040...80C. doi:10.1196/annals.1327.009. PMID 15891009.
• Thuau R, Guilhaudis L, Ségalas-Milazzo I, et al. (2005). "Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity.". Peptides. 26 (5): 779–89. doi:10.1016/j.peptides.2005.01.006. PMID 15808908.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chartrel N, Dujardin C, Anouar Y, et al. (2004). "Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity". Proc. Natl. Acad. Sci. U.S.A. 100 (25): 15247–52. Bibcode:2003PNAS..10015247C. doi:10.1073/pnas.2434676100. PMC 299975. PMID 14657341.
• Fukusumi S, Yoshida H, Fujii R, et al. (2004). "A new peptidic ligand and its receptor regulating adrenal function in rats.". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.
• Jiang Y, Luo L, Gustafson EL, et al. (2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.