RAPGEF6

RAPGEF6
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2D93, 3LNY
Identifiers
Aliases	RAPGEF6, KIA001LB, PDZ-GEF2, PDZGEF2, RA-GEF-2, RAGEF2, Rap guanine nucleotide exchange factor 6
External IDs	MGI: 2384761 HomoloGene: 22968 GeneCards: RAPGEF6
Gene ontology Molecular function • phosphatidic acid binding • GTP-dependent protein binding • protein binding • Ras GTPase binding • guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • plasma membrane • endocytic vesicle • apical plasma membrane • membrane Biological process • regulation of GTPase activity • small GTPase mediated signal transduction • positive regulation of GTPase activity • Ras protein signal transduction • microvillus assembly • protein localization to plasma membrane • establishment of endothelial intestinal barrier • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51735	192786
Ensembl	ENSG00000158987	ENSMUSG00000037533
UniProt	Q8TEU7	n/a
RefSeq (mRNA)	NM_016340 NM_001164386 NM_001164387 NM_001164388 NM_001164389 NM_001164390	NM_001252494 NM_001252496 NM_001252497 NM_001252498 NM_175258
RefSeq (protein)	NP_001157858.1 NP_001157859.1 NP_001157860.1 NP_001157861.1 NP_001157862.1 NP_057424.3	n/a
Location (UCSC)	Chr 5: 131.42 – 131.64 Mb	Chr 11: 54.52 – 54.7 Mb
PubMed search	[1]	[2]
Wikidata

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Rap guanine nucleotide exchange factor 6 is a protein that in humans is encoded by the RAPGEF6 gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T (Nov 2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". J Biol Chem. 276 (45): 42219–42225. doi:10.1074/jbc.M105760200. PMID 11524421.
4. Kozlov G, Banville D, Gehring K, Ekiel I (Jul 2002). "Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions". J Mol Biol. 320 (4): 813–820. doi:10.1016/S0022-2836(02)00544-2. PMID 12095257.
5. "Entrez Gene: RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Chen X, Wang X, Hossain S, et al. (2006). "Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia". Hum. Mol. Genet. 15 (22): 3329–3342. doi:10.1093/hmg/ddl409. PMID 17030554.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Kuiperij HB, de Rooij J, Rehmann H, et al. (2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochim. Biophys. Acta. 1593 (2–3): 141–149. doi:10.1016/S0167-4889(02)00365-8. PMID 12581858.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.