RASGRF1

RASGRF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IJE
Identifiers
Aliases	RASGRF1, CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1, Ras protein specific guanine nucleotide releasing factor 1
External IDs	MGI: 99694 HomoloGene: 74972 GeneCards: RASGRF1
Genetically Related Diseases
refractive error[1]
Gene ontology Molecular function • Rho guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity • glutamate receptor binding • Ras guanyl-nucleotide exchange factor activity Cellular component • cytosol • growth cone • neuron projection • plasma membrane Biological process • intracellular signal transduction • MAPK cascade • regulation of Rho protein signal transduction • positive regulation of GTPase activity • signal transduction • regulation of Rac protein signal transduction • regulation of synaptic plasticity • long-term memory • regulation of Ras protein signal transduction • regulation of neuronal synaptic plasticity • neuron projection development • regulation of N-methyl-D-aspartate selective glutamate receptor activity • activation of GTPase activity • cell proliferation • small GTPase mediated signal transduction • positive regulation of Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5923	19417
Ensembl	ENSG00000058335	ENSMUSG00000032356
UniProt	Q13972	P27671
RefSeq (mRNA)	NM_001145648 NM_002891 NM_153815	NM_001039655 NM_011245
RefSeq (protein)	NP_002882.3 NP_722522.1	NP_035375.1
Location (UCSC)	Chr 15: 78.96 – 79.09 Mb	Chr 9: 89.91 – 90.03 Mb
PubMed search	[2]	[3]
Wikidata

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View/Edit Mouse

Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene. ^[4]

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein.

The studies of the similar gene in mice suggested that the Ras-GEF activity of this protein in the brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009].

References

1. "Diseases that are genetically associated with RASGRF1 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. "Entrez Gene: Ras protein-specific guanine nucleotide-releasing factor 1". Retrieved 2013-04-07.

Further reading