RBPMS

RBPMS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5DET, 5CYJ
Identifiers
Aliases	RBPMS, HERMES, RNA binding protein with multiple splicing
External IDs	MGI: 1334446 HomoloGene: 38238 GeneCards: RBPMS
Gene ontology Molecular function • nucleotide binding • transcription coactivator activity • poly(A) RNA binding • snRNA binding • protein binding • poly(A) binding • nucleic acid binding • protein homodimerization activity • RNA binding Cellular component • nucleus • nucleoplasm • P-body • cytoplasm • cytoplasmic stress granule Biological process • mRNA splicing, via spliceosome • positive regulation of pathway-restricted SMAD protein phosphorylation • RNA processing • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of SMAD protein import into nucleus • response to oxidative stress Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11030	19663
Ensembl	ENSG00000157110	ENSMUSG00000031586
UniProt	Q93062	Q9WVB0
RefSeq (mRNA)	NM_001008710 NM_001008711 NM_001008712 NM_006867	NM_001042674 NM_001042675 NM_001286168 NM_019733
RefSeq (protein)	NP_001008710.1 NP_001008711.1 NP_001008712.1 NP_006858.1	NP_001036139.1 NP_001036140.1 NP_062707.1
Location (UCSC)	Chr 8: 30.38 – 30.57 Mb	Chr 8: 33.78 – 33.93 Mb
PubMed search	[1]	[2]
Wikidata

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RNA-binding protein with multiple splicing is a protein that in humans is encoded by the RBPMS gene.^[3][4]

Function

This gene encodes a member of the RRM family of RNA-binding proteins. The RRM domain is between 80-100 amino acids in length and family members contain one to four copies of the domain. The RRM domain consists of two short stretches of conserved sequence called RNP1 and RNP2, as well as a few highly conserved hydrophobic residues. The protein encoded by this gene has a single, putative RRM domain in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms.^[4]

It is uniquely expressed in retinal ganglion cells in the mammalian retina,^[5] for reasons unknown.

Interactions

RBPMS has been shown to interact with SMUG1.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Shimamoto A, Kitao S, Ichikawa K, Suzuki N, Yamabe Y, Imamura O, Tokutake Y, Satoh M, Matsumoto T, Kuromitsu J, Kataoka H, Sugawara K, Sugawara M, Sugimoto M, Goto M, Furuichi Y (Nov 1996). "A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10913–7. doi:10.1073/pnas.93.20.10913. PMC 38257. PMID 8855282.
4. "Entrez Gene: RBPMS RNA binding protein with multiple splicing".
5. Rodriguez AR, de Sevilla Müller LP, Brecha NC (Mar 2014). "The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina". J. Comp. Neurol. 522 (6): 1411–43. doi:10.1002/cne.23521. PMID 24318667.
6. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Hillman RT, Green RE, Brenner SE (2004). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.