40S ribosomal protein S26

RPS26
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 3J7R, 4D61, 4D5L, 4UJD, 3J7P, 4UJE, 4UJC
Identifiers
Aliases	RPS26, DBA10, S26, ribosomal protein S26
External IDs	MGI: 1351628 HomoloGene: 37420 GeneCards: RPS26
Gene ontology Molecular function • structural constituent of ribosome • protein binding • poly(A) RNA binding • mRNA binding • cadherin binding involved in cell-cell adhesion Cellular component • cytoplasm • cytosol • ribosome • membrane • intracellular ribonucleoprotein complex • intracellular • cytosolic small ribosomal subunit • nucleolus • small ribosomal subunit • extracellular exosome • cell-cell adherens junction • nucleoplasm Biological process • viral transcription • SRP-dependent cotranslational protein targeting to membrane • translational initiation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • negative regulation of RNA splicing • cell-cell adhesion • translation • rRNA processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6231	27370
Ensembl	ENSG00000197728	ENSMUSG00000025362
UniProt	P62854	P62855
RefSeq (mRNA)	NM_001029	NM_013765
RefSeq (protein)	NP_001020.2	NP_038793.2
Location (UCSC)	Chr 12: 56.04 – 56.04 Mb	Chr 10: 128.62 – 128.63 Mb
PubMed search	[1]	[2]
Wikidata

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40S ribosomal protein S26 is a protein that in humans is encoded by the RPS26 gene.^[3][4][5]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
4. Filipenko ML, Mishin VP, Suturina IuA, Muravlev AI, Kopantsev EA, Karpova GG, Mertvetsov NP (Aug 1996). "[Mapping of the genes for ribosomal proteins S26, L19, and L32 on human chromosomes]". Bioorg Khim. 21 (11): 838–44. PMID 8670309.
5. "Entrez Gene: RPS26 ribosomal protein S26".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Filipenko ML, Vladimirov SN, Muravlev AI, et al. (1994). "[Cloning cDNA of human S26 ribosomal protein and determination of its primary structure]". Bioorg. Khim. 20 (6): 644–9. PMID 7945460.
• Vincent S, Marty L, Fort P (1993). "S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues.". Nucleic Acids Res. 21 (6): 1498. doi:10.1093/nar/21.6.1498. PMC 309346. PMID 8464749.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Filipenko ML, Vinichenko NA, Karpova GG, et al. (1998). "Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26.". Gene. 211 (2): 287–92. doi:10.1016/S0378-1119(98)00108-5. PMID 9602156.
• Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
• Ivanov AV, Malygin AA, Karpova GG (2002). "[Ribosomal protein binding with the first intron of the human ribosomal protein S26 pre-mRNA stimulates its interaction with proteins extracted from Hela cells]". Mol. Biol. (Mosk.). 36 (3): 503–10. PMID 12068637.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ivanov AV, Malygin AA, Karpova GG (2005). "Human ribosomal protein S26 suppresses the splicing of its pre-mRNA.". Biochim. Biophys. Acta. 1727 (2): 134–40. doi:10.1016/j.bbaexp.2004.12.011. PMID 15716004.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes.". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.". Mol. Cell Proteomics. 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• GeneReviews/NCBI/NIH/UW entry on Diamond-Blackfan Anemia