Randall–Selitto test

The Randall–Selitto test or paw pressure test is a technique for the measurement of the pain response in animals. It is used in basic pain research and to test the effectiveness of analgetics by observing the reaction to gradually increasing pressure on an inflamed paw.^[1]^[2] Pain is deemed to be present if the animal starts to exhibit the flight or struggle response.^[3]

Randall and Selitto exploited the fact that inflammation increases pain sensitivity and this sensitivity is modifiable by analgesics. The inflammation may be induced by injecting a dry yeast suspension into the underside of the hind limb.^[3]

References

↑ Lal, H.; Fielding, S. (1981). Psychopharmacology of Clonidine. Liss. ISBN 9780845100714. Retrieved 2015-03-24.
↑ Randall and Selitto, Archives Internationales de Pharmacodynamie et de Thérapie, 1957, vol. 133, p. 233)
1 2 PHARMACOLOGICAL EVALUATION OF MILD ANALGESICS, D. Roemer, Br. J. Clin. Pharmac. (1980), 10, 247S–251S

Pain and nociception

By region/system

HEENT	Headache Neck Odynophagia (swallowing) Toothache

Respiratory system	Sore throat Pleurodynia

Musculoskeletal	Arthralgia (joint) Bone pain Myalgia (muscle) Muscle soreness: Acute / Delayed onset

Neurologic	Congenital insensitivity to pain HSAN Type I II congenital sensory neuropathy III familial dysautonomia IV congenital insensitivity to pain with anhidrosis V congenital insensitivity to pain with partial anhidrosis Neuralgia Pain asymbolia Pain disorder Paroxysmal extreme pain disorder Allodynia Chronic pain Hyperalgesia Hypoalgesia Hyperpathia Phantom pain Referred pain

Other	Pelvic pain Proctalgia Back

Tests

Related concepts

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