Rate of infusion

In pharmacokinetics, the rate of infusion (or dosing rate) refers not just to the rate at which a drug is administered, but the desired rate at which a drug should be administered to achieve a steady state of a fixed dose which has been demonstrated to be therapeutically effective.

Abbreviations include K_in,^[1] K₀,^[2] or R₀.

It can be calculated as the steady-state concentration in the plasma multiplied by the clearance:

${\displaystyle \textstyle K_{in}=C_{ss}\cdot CL}$

References

1. "Cp vs time - iv infusion".
2. "Chapter 15.2 - Continuous IV Infusion - Steady State".