Replication stress

Replication stress is a stress occurring during DNA replication, typically resulting in a stalled replication fork. Replication stress can be due to DNA damage, excessive compacting of chromatin (preventing replisome access), over-expression of oncogenes, or difficult-to-replicate genome structures.[1][2] ATM and ATR (kinases recruited and activated by DNA damage) proteins mediate replication stress.[1][2] Replication stress can lead to genome instability, cancer, and ageing.[3]

References

  1. 1 2 Mazouzi A, Velimezi G, Loizou JI (2014). "DNA replication stress: causes, resolution and disease". Experimental Cell Research. 329 (1): 85–93. doi:10.1016/j.yexcr.2014.09.030. PMID 25281304.
  2. 1 2 Zeman MK, Cimprich KA (2014). "Causes and consequences of replication stress". Nature Cell Biology. 16 (1): 2–9. doi:10.1038/ncb2897. PMC 4354890Freely accessible. PMID 24366029.
  3. ↑ Burhans WC1, Weinberger M (2007). "DNA replication stress, genome instability and aging". Nucleic Acids Research. 35 (22): 7545–7556. doi:10.2217/imt.10.107. PMC 2190710Freely accessible. PMID 18055498.

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