SEMA3B

SEMA3B
Identifiers
Aliases	SEMA3B, LUCA-1, SEMA5, SEMAA, SemA, semaV, semaphorin 3B
External IDs	MGI: 107561 HomoloGene: 20972 GeneCards: SEMA3B
Gene ontology Molecular function • neuropilin binding • semaphorin receptor binding • chemorepellent activity Cellular component • extracellular region • extracellular fluid • extracellular exosome • endoplasmic reticulum Biological process • negative chemotaxis • positive regulation of cell migration • semaphorin-plexin signaling pathway • axon guidance • neural crest cell migration • cell-cell signaling • negative regulation of axon extension involved in axon guidance Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7869	20347
Ensembl	ENSG00000012171	ENSMUSG00000057969
UniProt	Q13214	Q62177
RefSeq (mRNA)	NM_001005914 NM_001290060 NM_001290061 NM_001290062 NM_001290063 NM_004636	NM_001042779 NM_001291537 NM_001291538 NM_001291539 NM_009153
RefSeq (protein)	NP_001005914.1 NP_001276989.1 NP_001276990.1 NP_001276991.1 NP_001276992.1 NP_004627.1	n/a
Location (UCSC)	Chr 3: 50.27 – 50.28 Mb	Chr 9: 107.6 – 107.61 Mb
PubMed search	[1]	[2]
Wikidata

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Semaphorin-3B is a protein that in humans is encoded by the SEMA3B gene.^[3][4][5]

The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Puschel AW; Adams RH; Betz H (Jun 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
4. Sekido Y; Bader S; Latif F; Chen JY; Duh FM; Wei MH; Albanesi JP; Lee CC; Lerman MI; Minna JD (Jul 1996). "Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns". Proc Natl Acad Sci U S A. 93 (9): 4120–5. doi:10.1073/pnas.93.9.4120. PMC 39497. PMID 8633026.
5. "Entrez Gene: SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B".

Further reading

• Wei MH, Latif F, Bader S, et al. (1996). "Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG". Cancer Res. 56 (7): 1487–92. PMID 8603390.
• Takahashi T, Nakamura F, Jin Z, et al. (1999). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors". Nat. Neurosci. 1 (6): 487–93. doi:10.1038/2203. PMID 10196546.
• Lerman MI; Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID 11085536.
• Tomizawa Y, Sekido Y, Kondo M, et al. (2002). "Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13954–9. doi:10.1073/pnas.231490898. PMC 61148. PMID 11717452.
• Tse C; Xiang RH; Bracht T; Naylor SL (2002). "Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line". Cancer Res. 62 (2): 542–6. PMID 11809707.
• Ochi K, Mori T, Toyama Y, et al. (2002). "Identification of semaphorin3B as a direct target of p53". Neoplasia. 4 (1): 82–7. doi:10.1038/sj/neo/7900211. PMC 1503310. PMID 11922394.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kuroki T, Trapasso F, Yendamuri S, et al. (2003). "Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer". Cancer Res. 63 (12): 3352–5. PMID 12810670.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Castro-Rivera E; Ran S; Thorpe P; Minna JD (2004). "Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect". Proc. Natl. Acad. Sci. U.S.A. 101 (31): 11432–7. doi:10.1073/pnas.0403969101. PMC 509218. PMID 15273288.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Marsit CJ; Wiencke JK; Liu M; Kelsey KT (2005). "The race associated allele of Semaphorin 3B (SEMA3B) T415I and its role in lung cancer in African-Americans and Latino-Americans". Carcinogenesis. 26 (8): 1446–9. doi:10.1093/carcin/bgi098. PMID 15831529.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Nair PN, McArdle L, Cornell J, et al. (2007). "High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene". Cancer Genet. Cytogenet. 174 (2): 100–10. doi:10.1016/j.cancergencyto.2006.11.017. PMID 17452250.