SERPINB8

SERPINB8
Identifiers
Aliases	SERPINB8, CAP2, PI8, serpin family B member 8
External IDs	MGI: 894657 HomoloGene: 74445 GeneCards: SERPINB8
Gene ontology Molecular function • peptidase inhibitor activity • protein binding • serine-type endopeptidase inhibitor activity Cellular component • cytoplasm • extracellular fluid • cytosol • extracellular exosome Biological process • negative regulation of peptidase activity • negative regulation of endopeptidase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5271	20725
Ensembl	ENSG00000166401	ENSMUSG00000026315
UniProt	P50452	O08800
RefSeq (mRNA)	NM_001031848 NM_001276490 NM_002640 NM_198833	NM_001159748 NM_011459
RefSeq (protein)	NP_001027018.1 NP_001263419.1 NP_002631.3 NP_942130.1	NP_035589.1
Location (UCSC)	Chr 18: 63.97 – 64.01 Mb	Chr 1: 107.59 – 107.61 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Serpin B8 is a protein that in humans is encoded by the SERPINB8 gene.^[3][4][5]

See also

• Serpin

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Sprecher CA, Morgenstern KA, Mathewes S, Dahlen JR, Schrader SK, Foster DC, Kisiel W (Jan 1996). "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors". J Biol Chem. 270 (50): 29854–61. doi:10.1074/jbc.270.50.29854. PMID 8530382.
4. Bartuski AJ, Kamachi Y, Schick C, Overhauser J, Silverman GA (Nov 1997). "Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3". Genomics. 43 (3): 321–8. doi:10.1006/geno.1997.4827. PMID 9268635.
5. "Entrez Gene: SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8".

Further reading

• Hubberstey A, Yu G, Loewith R, et al. (1997). "Mammalian CAP interacts with CAP, CAP2, and actin.". J. Cell. Biochem. 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. PMID 8761950.
• Dahlen JR, Foster DC, Kisiel W (1998). "Expression, purification, and inhibitory properties of human proteinase inhibitor.". Biochemistry. 36 (48): 14874–82. doi:10.1021/bi970977p. PMID 9402754.
• Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method.". Genomics. 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
• Dahlen JR, Jean F, Thomas G, et al. (1998). "Inhibition of soluble recombinant furin by human proteinase inhibitor 8.". J. Biol. Chem. 273 (4): 1851–4. doi:10.1074/jbc.273.4.1851. PMID 9442015.
• Strik MC, Bladergroen BA, Wouters D, et al. (2003). "Distribution of the human intracellular serpin protease inhibitor 8 in human tissues.". J. Histochem. Cytochem. 50 (11): 1443–54. doi:10.1177/002215540205001103. PMID 12417609.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hoetelmans RW (2004). "Nuclear partners of Bcl-2: Bax and PML.". DNA Cell Biol. 23 (6): 351–4. doi:10.1089/104454904323145236. PMID 15231068.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Leblond J, Laprise MH, Gaudreau S, et al. (2006). "The serpin proteinase inhibitor 8: an endogenous furin inhibitor released from human platelets.". Thromb. Haemost. 95 (2): 243–52. doi:10.1267/THRO06020243. PMID 16493485.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.013
• SERPINB8 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)