SH3GLB2

SH3GLB2
Identifiers
Aliases	SH3GLB2, PP6569, PP9455, RRIG1, SH3 domain containing GRB2 like endophilin B2
External IDs	MGI: 2385131 HomoloGene: 10595 GeneCards: SH3GLB2
Gene ontology Molecular function • protein binding • identical protein binding • cadherin binding involved in cell-cell adhesion Cellular component • cytoplasm • nucleus • cell-cell adherens junction Biological process • cell-cell adhesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56904	227700
Ensembl	ENSG00000148341	ENSMUSG00000026860
UniProt	Q9NR46	Q8R3V5
RefSeq (mRNA)	NM_001287045 NM_001287046 NM_020145	NM_001289709 NM_001289710 NM_139302
RefSeq (protein)	NP_001273974.1 NP_001273975.1 NP_064530.1	NP_001276638.1 NP_647463.1
Location (UCSC)	Chr 9: 129.01 – 129.03 Mb	Chr 2: 30.34 – 30.36 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Endophilin-B2 is a protein that in humans is encoded by the SH3GLB2 gene.^[3][4]

Interactions

SH3GLB2 has been shown to interact with SH3GLB1^[3] and SH3KBP1.^[5][6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Pierrat B, Simonen M, Cueto M, Mestan J, Ferrigno P, Heim J (February 2001). "SH3GLB, a new endophilin-related protein family featuring an SH3 domain". Genomics. 71 (2): 222–34. doi:10.1006/geno.2000.6378. PMID 11161816.
4. "Entrez Gene: SH3GLB2 SH3-domain GRB2-like endophilin B2".
5. Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
6. Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. doi:10.1038/416183a. PMID 11894095.

Further reading

• Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins.". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mikula M, Dzwonek A, Karczmarski J, Rubel T, Dadlez M, Wyrwicz LS, Bomsztyk K, Ostrowski J (2006). "Landscape of the hnRNP K protein-protein interactome.". Proteomics. 6 (8): 2395–406. doi:10.1002/pmic.200500632. PMID 16518874.