SHOC2

SHOC2
Identifiers
Aliases SHOC2, SIAA0862, SOC2, SUR8, SHOC2 leucine-rich repeat scaffold protein, leucine rich repeat scaffold protein
External IDs MGI: 1927197 HomoloGene: 7219 GeneCards: SHOC2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

8036

56392

Ensembl

ENSG00000108061

ENSMUSG00000024976

UniProt

Q9UQ13

O88520

RefSeq (mRNA)

NM_001269039
NM_007373
NM_001324336
NM_001324337

NM_001168505
NM_019658

RefSeq (protein)

NP_001255968.1
NP_031399.2
NP_001311265.1
NP_001311266.1

NP_001161977.1
NP_062632.2

Location (UCSC) Chr 10: 110.92 – 111.01 Mb Chr 19: 53.94 – 54.03 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Leucine-rich repeat protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene.[3][4][5][6] Mutations that result in lipidation (specifically Myristoylation) of SHOC2 can cause Noonan syndrome.[7]

Interactions

SHOC2 has been shown to interact with C-Raf[5] and HRAS.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Selfors LM, Schutzman JL, Borland CZ, Stern MJ (Jul 1998). "soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6903–8. doi:10.1073/pnas.95.12.6903. PMC 22679Freely accessible. PMID 9618511.
  4. Sieburth DS, Sun Q, Han M (Aug 1998). "SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans". Cell. 94 (1): 119–30. doi:10.1016/S0092-8674(00)81227-1. PMID 9674433.
  5. 1 2 3 Li W, Han M, Guan KL (May 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. 14 (8): 895–900. PMC 316541Freely accessible. PMID 10783161.
  6. "Entrez Gene: SHOC2 soc-2 suppressor of clear homolog (C. elegans)".
  7. Cordeddu V, Di Schiavi E, Pennacchio LA, Ma'ayan A, Sarkozy A, Fodale V, Cecchetti S, Cardinale A, Martin J, Schackwitz W, Lipzen A, Zampino G, Mazzanti L, Digilio MC, Martinelli S, Flex E, Lepri F, Bartholdi D, Kutsche K, Ferrero GB, Anichini C, Selicorni A, Rossi C, Tenconi R, Zenker M, Merlo D, Dallapiccola B, Iyengar R, Bazzicalupo P, Gelb BD, Tartaglia M (Sep 2009). "Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair". Nature Genetics. 41 (9): 1022–6. doi:10.1038/ng.425. PMID 19684605.

Further reading

  • Dai P, Xiong WC, Mei L (2006). "Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex". J. Biol. Chem. 281 (2): 927–33. doi:10.1074/jbc.M507360200. PMID 16301319. 
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485. 


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