SYT5

SYT5
Identifiers
Aliases	SYT5
External IDs	MGI: 1926368 HomoloGene: 55722 GeneCards: SYT5
Gene ontology Molecular function • calcium ion binding • clathrin binding • metal ion binding • protein heterodimerization activity • calcium-dependent phospholipid binding • syntaxin binding • SNARE binding • phosphatidylinositol-4,5-bisphosphate binding • phosphatidylserine binding Cellular component • integral component of membrane • endosome • membrane • synapse • synaptic vesicle membrane • cell junction • neuronal cell body • recycling endosome membrane • perinuclear region of cytoplasm • neuron projection • dense core granule • cytoplasmic vesicle • plasma membrane Biological process • synaptic vesicle endocytosis • chemical synaptic transmission • vesicle fusion • regulation of calcium ion-dependent exocytosis • calcium ion-regulated exocytosis of neurotransmitter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6861	53420
Ensembl	ENSG00000129990	ENSMUSG00000004961
UniProt	O00445	Q9R0N5
RefSeq (mRNA)	NM_001297774 NM_003180	NM_016908
RefSeq (protein)	NP_001284703.1 NP_003171.2	NP_058604.1
Location (UCSC)	Chr 19: 55.17 – 55.18 Mb	Chr 7: 4.54 – 4.55 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Synaptotagmin-5 is a protein that in humans is encoded by the SYT5 gene.^[3][4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Craxton M, Olsen A, Goedert M (Jul 1997). "Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location". Genomics. 42 (1): 165–9. doi:10.1006/geno.1997.4722. PMID 9177789.
4. "Entrez Gene: SYT5 synaptotagmin V".

Further reading

• Hudson AW, Birnbaum MJ (1995). "Identification of a nonneuronal isoform of synaptotagmin.". Proc. Natl. Acad. Sci. U.S.A. 92 (13): 5895–9. doi:10.1073/pnas.92.13.5895. PMC 41608. PMID 7597049.
• Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin.". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
• Fukuda M, Kanno E, Mikoshiba K (1999). "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X.". J. Biol. Chem. 274 (44): 31421–7. doi:10.1074/jbc.274.44.31421. PMID 10531343.
• Craxton M, Goedert M (1999). "Alternative splicing of synaptotagmins involving transmembrane exon skipping.". FEBS Lett. 460 (3): 417–22. doi:10.1016/S0014-5793(99)01382-4. PMID 10556508.
• Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.". J. Biol. Chem. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sreenath AS, Kumar KR, Reddy GV, et al. (2005). "Evidence for the association of synaptotagmin with glutathione S-transferases: implications for a novel function in human breast cancer.". Clin. Biochem. 38 (5): 436–43. doi:10.1016/j.clinbiochem.2005.01.009. PMID 15820774.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.