Sebaceous adenoma

Sebaceous adenoma
Micrograph of a sebaceous adenoma. H&E stain.
Classification and external resources
MedlinePlus	002292

A sebaceous adenoma, a type of adenoma, a cutaneous condition characterized by a slow-growing tumor usually presenting as a pink, flesh-coloured, or yellow papule or nodule.^[1]:662[2]

Significance

Sebaceous adenomas, in isolation, are not significant; however, they may be associated with Muir-Torre syndrome, a genetic condition that predisposes individuals to cancer.^[3] It is also linked to hereditary nonpolyposis colorectal cancer (Lynch Syndrome).

It is not the same as "adenoma sebaceum" by F. Balzer and P.E. Ménétrier (1885).^[4] The term "adenoma sebaceum" is a misnomer for facial angiofibromas associated with tuberous sclerosis complex.^{[5][lower-alpha 1][lower-alpha 2]}

See also

• Sebaceous carcinoma
• Sebaceous hyperplasia
• List of cutaneous conditions
• List of cutaneous neoplasms associated with systemic syndromes

References

Footnotes

1. Balzer and Menetrier (1885) described the microscopic appearance of the facial papules as "adenoma sebaceum", thought to be benign tumors of sebaceous glands, although the skin lesions are actually angiofibromas.

   — Semi D., Vivian A., Taylor D., Saunders D. 1993, Chapter 36. Vol.5. Duane's Clinical Ophthalmology.^[6]

2. Facial angiofibromas were first described in 1885 by Balzer and Menetrier. At this time, they were incorrectly termed adenoma sebaceum. We now know that the sebaceous glands are only passively involved, if at all. Facial angiofibromas are actually hamartomas, defined as benign, tumorous nodules of superfluous tissue.

   — Tuberous Sclerosis Alliance., Treatment of tuberous sclerosis complex dermatological lesions.^[7]

Citations

1. James et al. 2006
2. Rapini et al. 2007
3. Online Mendelian Inheritance in Man (OMIM) 158320
4. Balzer et al. 1885
5. Morgan et al. 1979
6. Sami et al. 1993
7. Tuberous Sclerosis Alliance. 2008

Sources

• Balzer F.; Ménétrier P. (1885). "Étude sur un cas d'adénomes sébacés de la face et du cuir". Archives de Physiologie normale et pathologique. Paris. 6 (3): 564–676.
• James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
• Morgan, J.E.; Wolfort F. (1979). "The Early History of Tuberous Sclerosis". Arch Dermatol. 115 (11): 1317–1319. doi:10.1001/archderm.1979.04010110023018. PMID 389165.
• Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 1702, 1703. ISBN 1-4160-2999-0.
• Sami, David; Vivian, Antony; Taylor, David; Saunders, Down (1993). "36. The Phakomatoses". In Duane, Thomas. Duane's Clinical Ophthalmology. 5. Lippincott Williams & Wilkins. ISBN 039757245X.
• "Treatment of tuberous sclerosis complex dermatological lesions" (PDF). Tuberous Sclerosis Alliance, Derm Outreach Packet, p.7. tsalliance.org. 11 December 2008. Retrieved 2015-03-08.