Small nucleolar RNA snR66

Small nucleolar RNA snR66

Predicted secondary structure and sequence conservation of snosnR66
Identifiers
Symbol snosnR66
Rfam RF00477
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

snoRNA snR66 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA snR66 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] snoRNA snR66 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome.[2]

References

  1. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041Freely accessible. PMID 12215523.
  2. ↑ Lowe, T. M.; Eddy, S. R. (February 1999). "A Computational Screen for Methylation Guide snoRNAs in Yeast". Science. 283 (5405): 1168–1171. Bibcode:1999Sci...283.1168L. doi:10.1126/science.283.5405.1168. PMID 10024243.


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