TAC3

TAC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P9F
Identifiers
Aliases	TAC3, HH10, NKB, NKNB, PRO1155, ZNEUROK1, tachykinin 3
External IDs	MGI: 98476 HomoloGene: 7560 GeneCards: TAC3
Gene ontology Molecular function • receptor binding • protein binding Cellular component • extracellular fluid • extracellular region • extracellular exosome Biological process • female pregnancy • neuropeptide signaling pathway • tachykinin receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6866	21334
Ensembl	ENSG00000166863	ENSMUSG00000025400
UniProt	Q9UHF0	P55099
RefSeq (mRNA)	NM_001006667 NM_001178054 NM_013251	NM_001199971 NM_009312
RefSeq (protein)	NP_001171525.1 NP_037383.1	NP_001186900.1 NP_033338.2
Location (UCSC)	Chr 12: 57.01 – 57.03 Mb	Chr 10: 127.72 – 127.73 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Tachykinin-3 is a protein that in humans is encoded by the TAC3 gene.^[3][4][5]

See also

• Neurokinin B
• Tachykinin receptor 3

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Bonner TI, Affolter HU, Young AC, Young WS (Jan 1988). "A cDNA encoding the precursor of the rat neuropeptide, neurokinin B". Brain Res. 388 (3): 243–9. PMID 3479225.
4. Page NM, Woods RJ, Gardiner SM, Lomthaisong K, Gladwell RT, Butlin DJ, Manyonda IT, Lowry PJ (Jul 2000). "Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia". Nature. 405 (6788): 797–800. doi:10.1038/35015579. PMID 10866201.
5. "Entrez Gene: TAC3 tachykinin 3 (neuromedin K, neurokinin beta)".

Further reading

• Page NM, Woods RJ, Lowry PJ (2001). "A regulatory role for neurokinin B in placental physiology and pre-eclampsia.". Regul. Pept. 98 (3): 97–104. doi:10.1016/S0167-0115(00)00239-1. PMID 11231038.
• Rance NE, Young WS (1991). "Hypertrophy and increased gene expression of neurons containing neurokinin-B and substance-P messenger ribonucleic acids in the hypothalami of postmenopausal women.". Endocrinology. 128 (5): 2239–47. doi:10.1210/endo-128-5-2239. PMID 1708331.
• Bhogal N, Donnelly D, Findlay JB (1994). "The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor.". J. Biol. Chem. 269 (44): 27269–74. PMID 7961636.
• Tian Y, Wu LH, Oxender DL, Chung FZ (1996). "The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity.". J. Biol. Chem. 271 (34): 20250–7. doi:10.1074/jbc.271.34.20250. PMID 8702757.
• Krause JE, Staveteig PT, Mentzer JN, et al. (1997). "Functional expression of a novel human neurokinin-3 receptor homolog that binds 3Hsenktide and 125I-MePhe7neurokinin B, and is responsive to tachykinin peptide agonists". Proc. Natl. Acad. Sci. U.S.A. 94 (1): 310–5. doi:10.1073/pnas.94.1.310. PMC 19326. PMID 8990205.
• Brunelleschi S, Bordin G, Colangelo D, Viano I (1999). "Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis". Neuropeptides. 32 (3): 215–23. doi:10.1016/S0143-4179(98)90040-3. PMID 10189055.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brownbill P, Bell NJ, Woods RJ, et al. (2003). "Neurokinin B is a paracrine vasodilator in the human fetal placental circulation". J. Clin. Endocrinol. Metab. 88 (5): 2164–70. doi:10.1210/jc.2002-021727. PMID 12727971.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Schlembach D, Scalera F, Fischer T, et al. (2003). "Neurokinin B peptide serum levels are higher in normotensive pregnant women than in preeclamptic pregnant women". Am. J. Obstet. Gynecol. 189 (5): 1418–22. doi:10.1067/S0002-9378(03)00775-0. PMID 14634580.
• Laliberte C, DiMarzo L, Morrish DW, Kaufman S (2004). "Neurokinin B causes concentration-dependent relaxation of isolated human placental resistance vessels". Regul. Pept. 117 (2): 123–6. doi:10.1016/j.regpep.2003.10.032. PMID 14700748.
• Pal S, Nemeth MJ, Bodine D, et al. (2004). "Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1". J. Biol. Chem. 279 (30): 31348–56. doi:10.1074/jbc.M403475200. PMID 15123623.
• Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM (2005). "Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles". J. Biomol. Struct. Dyn. 22 (2): 137–48. doi:10.1080/07391102.2004.10506990. PMID 15317475.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Page NM, Dakour J, Morrish DW (2006). "Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia". Mol. Hum. Reprod. 12 (7): 427–33. doi:10.1093/molehr/gal025. PMID 16709596.