TBL1XR1

TBL1XR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LG9
Identifiers
Aliases	TBL1XR1, C21, DC42, IRA1, TBLR1, MRD41, transducin (beta)-like 1 X-linked receptor 1
External IDs	MGI: 2441730 HomoloGene: 69382 GeneCards: TBL1XR1
Gene ontology Molecular function • DNA binding • beta-catenin binding • transcription corepressor activity • protein N-terminus binding • histone binding • protein binding • transcription regulatory region DNA binding Cellular component • histone deacetylase complex • transcriptional repressor complex • nucleoplasm • spindle microtubule • nucleus Biological process • fat pad development • response to dietary excess • regulation of transcription, DNA-templated • cellular lipid metabolic process • multicellular organism growth • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of transcription, DNA-templated • lipid catabolic process • regulation of triglyceride metabolic process • regulation of cAMP metabolic process • white fat cell differentiation • canonical Wnt signaling pathway • regulation of gene expression • adipose tissue development • negative regulation of transcription, DNA-templated • histone deacetylation • positive regulation of transcription from RNA polymerase II promoter • proteasome-mediated ubiquitin-dependent protein catabolic process • covalent chromatin modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79718	81004
Ensembl	ENSG00000177565	ENSMUSG00000027630
UniProt	Q9BZK7	Q8BHJ5
RefSeq (mRNA)	NM_024665 NM_001321193 NM_001321194 NM_001321195	NM_030732
RefSeq (protein)	NP_078941.2 NP_001308122.1 NP_001308123.1 NP_001308124.1	NP_109657.2
Location (UCSC)	Chr 3: 177.02 – 177.2 Mb	Chr 3: 22.08 – 22.22 Mb
PubMed search	[1]	[2]
Wikidata

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F-box-like/WD repeat-containing protein TBL1XR1 is a protein that in humans is encoded by the TBL1XR1 gene.^[3][4][5]

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation.^[5]

Interactions

TBL1XR1 has been shown to interact with Nuclear receptor co-repressor 1.^[4][6][7]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Zhang X, Dormady SP, Basch RS (Jan 2001). "Identification of four human cDNAs that are differentially expressed by early hematopoietic progenitors". Exp Hematol. 28 (11): 1286–96. doi:10.1016/S0301-472X(00)00539-7. PMID 11063877.
4. Zhang J, Kalkum M, Chait BT, Roeder RG (Apr 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol Cell. 9 (3): 611–23. doi:10.1016/S1097-2765(02)00468-9. PMID 11931768.
5. "Entrez Gene: TBL1XR1 transducin (beta)-like 1X-linked receptor 1".
6. Yoon, Ho-Geun; Chan Doug W; Reynolds Albert B; Qin Jun; Wong Jiemin (Sep 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Mol. Cell. United States. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. ISSN 1097-2765. PMID 14527417.
7. Yoon, Ho-Geun; Chan Doug W; Huang Zhi-Qing; Li Jiwen; Fondell Joseph D; Qin Jun; Wong Jiemin (Mar 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. England. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. ISSN 0261-4189. PMC 151047. PMID 12628926.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yoon HG, Chan DW, Huang ZQ, et al. (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
• Yoon HG, Chan DW, Reynolds AB, et al. (2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso.". Mol. Cell. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Perissi V, Aggarwal A, Glass CK, et al. (2004). "A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.". Cell. 116 (4): 511–26. doi:10.1016/S0092-8674(04)00133-3. PMID 14980219.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yoon HG, Choi Y, Cole PA, Wong J (2005). "Reading and function of a histone code involved in targeting corepressor complexes for repression.". Mol. Cell. Biol. 25 (1): 324–35. doi:10.1128/MCB.25.1.324-335.2005. PMC 538779. PMID 15601853.
• Zhang XM, Chang Q, Zeng L, et al. (2006). "TBLR1 regulates the expression of nuclear hormone receptor co-repressors.". BMC Cell Biol. 7: 31. doi:10.1186/1471-2121-7-31. PMC 1555579. PMID 16893456.
• Liu Y, Sun W, Zhang K, et al. (2007). "Identification of genes differentially expressed in human primary lung squamous cell carcinoma.". Lung Cancer. 56 (3): 307–17. doi:10.1016/j.lungcan.2007.01.016. PMID 17316888.