TRIP12

TRIP12
Identifiers
Aliases	TRIP12, TRIP-12, ULF, thyroid hormone receptor interactor 12
External IDs	MGI: 1309481 HomoloGene: 44226 GeneCards: TRIP12
Gene ontology Molecular function • thyroid hormone receptor binding • ligase activity • protein binding • ubiquitin-protein transferase activity Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol Biological process • negative regulation of double-strand break repair • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • negative regulation of histone H2A K63-linked ubiquitination • DNA repair • protein ubiquitination • embryo development • cellular response to DNA damage stimulus • protein polyubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9320	14897
Ensembl	ENSG00000153827	ENSMUSG00000026219
UniProt	Q14669	G5E870
RefSeq (mRNA)	NM_001284214 NM_001284215 NM_001284216 NM_004238	NM_133975
RefSeq (protein)	NP_001271143.1 NP_001271144.1 NP_001271145.1 NP_004229.1	NP_598736.4
Location (UCSC)	Chr 2: 229.76 – 229.92 Mb	Chr 1: 84.72 – 84.84 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Probable E3 ubiquitin-protein ligase TRIP12 is an enzyme that in humans is encoded by the TRIP12 gene.^[3][4]

Interactions

TRIP12 has been shown to interact with APPBP1.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974.
4. "Entrez Gene: TRIP12 thyroid hormone receptor interactor 12".
5. Park, Yoon; Yoon Sungjoo Kim; Yoon Jong-Bok (Sep 2008). "TRIP12 functions as an E3 ubiquitin ligase of APP-BP1". Biochem. Biophys. Res. Commun. United States. 374 (2): 294–8. doi:10.1016/j.bbrc.2008.07.019. PMID 18627766.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.