TSEN2

TSEN2
Identifiers
Aliases	TSEN2, PCH2B, SEN2, SEN2L, tRNA splicing endonuclease subunit 2
External IDs	MGI: 2141599 HomoloGene: 41622 GeneCards: TSEN2
Genetically Related Diseases
prostate cancer[1]
Gene ontology Molecular function • nuclease activity • tRNA-intron endonuclease activity • protein binding • lyase activity • nucleic acid binding Cellular component • cytoplasm • centrosome • nucleolus • nucleus • tRNA-intron endonuclease complex • nucleoplasm Biological process • mRNA processing • tRNA-type intron splice site recognition and cleavage • nucleic acid phosphodiester bond hydrolysis • RNA phosphodiester bond hydrolysis, endonucleolytic • tRNA splicing, via endonucleolytic cleavage and ligation • RNA phosphodiester bond hydrolysis • tRNA processing Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80746	381802
Ensembl	ENSG00000154743	ENSMUSG00000042389
UniProt	Q8NCE0	Q6P7W5
RefSeq (mRNA)	NM_001145392 NM_001145393 NM_001145394 NM_001145395 NM_025265 NM_001321277 NM_001321278 NM_001321279	NM_199033
RefSeq (protein)	NP_001138864.1 NP_001138865.1 NP_001138866.1 NP_079541.1 NP_001308206.1 NP_001308207.1 NP_001308208.1	NP_950198.1
Location (UCSC)	Chr 3: 12.48 – 12.54 Mb	Chr 6: 115.54 – 115.58 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

tRNA-splicing endonuclease subunit Sen2 is an enzyme that in humans is encoded by the TSEN2 gene.^[4][5]

tRNA splicing is a fundamental process required for cell growth and division. SEN2 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]^[5]

Interactions

TSEN2 has been shown to interact with TSEN34^[4] and C1orf19.^[4]

References

1. "Diseases that are genetically associated with TSEN2 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492.
5. "Entrez Gene: TSEN2 tRNA splicing endonuclease 2 homolog (S. cerevisiae)".

External links

• GeneReviews/NCBI/NIH/UW entry on Pontocerebellar Hypoplasia Type 2 and Type 4

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.