Trihydroxystilbene synthase

trihydroxystilbene synthase
Identifiers
EC number 2.3.1.95
CAS number 128449-70-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a trihydroxystilbene synthase (EC 2.3.1.95) is an enzyme that catalyzes the chemical reaction

3 malonyl-CoA + 4-coumaroyl-CoA 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2

Thus, the two substrates of this enzyme are malonyl-CoA and 4-coumaroyl-CoA, whereas its 3 products are CoA, 3,4',5-trihydroxy-stilbene (resveratrol), and CO2.

This enzyme belongs to the family of transferases, To be specific those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing). Other names in common use include resveratrol synthase, and stilbene synthase. This enzyme participates in phenylpropanoid biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Z1E[1] and 1Z1F.[1]

References

  1. 1 2 Shomura, Yasuhito; Torayama, Ichiro; Suh, Dae-Yeon; Xiang, Ting; Kita, Akiko; Sankawa, Ushio; Miki, Kunio (2005-09-01). "Crystal structure of stilbene synthase from Arachis hypogaea". Proteins: Structure, Function, and Bioinformatics. 60 (4): 803–806. doi:10.1002/prot.20584. ISSN 1097-0134.


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