Ubiquilin 4

UBQLN4
Identifiers
Aliases	UBQLN4, A1U, A1Up, C1orf6, CIP75, UBIN, Ubiquilin 4
External IDs	MGI: 2150152 HomoloGene: 41346 GeneCards: UBQLN4
Gene ontology Molecular function • polyubiquitin binding • protein binding • identical protein binding Cellular component • cytoplasm • perinuclear region of cytoplasm • autophagosome • nuclear proteasome complex • cytosolic proteasome complex • cytosol • endoplasmic reticulum membrane • cytoplasmic vesicle • endoplasmic reticulum • nucleus Biological process • autophagy • negative regulation of autophagosome maturation • regulation of proteasomal ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56893	94232
Ensembl	ENSG00000160803	ENSMUSG00000008604
UniProt	Q9NRR5	Q99NB8
RefSeq (mRNA)	NM_001304342 NM_020131	NM_033526
RefSeq (protein)	NP_001291271.1 NP_064516.2	NP_277068.1
Location (UCSC)	Chr 1: 156.04 – 156.05 Mb	Chr 3: 88.55 – 88.57 Mb
PubMed search	[1]	[2]
Wikidata

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Ubiquilin 4 is a protein in humans that is encoded by the UBQLN4 gene.^[3][4][5] Ubiquilin 4 regulates proteasomal protein degradation.^[6]

Similarity to Other Proteins

Human UBQLN4 shares a high degree of similarity with related ubiquilins including UBQLN1 and UBQLN2.^[7]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Ubiquilin 4". Retrieved 2013-06-27.
4. Davidson JD, Riley B, Burright EN, Duvick LA, Zoghbi HY, Orr HT (September 2000). "Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein". Hum. Mol. Genet. 9 (15): 2305–12. doi:10.1093/oxfordjournals.hmg.a018922. PMID 11001934.
5. Matsuda M, Koide T, Yorihuzi T, Hosokawa N, Nagata K (January 2001). "Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences". Biochem. Biophys. Res. Commun. 280 (2): 535–40. doi:10.1006/bbrc.2000.4149. PMID 11162551.
6. Riley BE, Xu Y, Zoghbi HY, Orr HT (October 2004). "The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up". J. Biol. Chem. 279 (40): 42290–301. doi:10.1074/jbc.M406284200. PMID 15280365.
7. Marín I (March 2014). "The ubiquilin gene family: evolutionary patterns and functional insights". BMC Evol Biol. 14: 63. doi:10.1186/1471-2148-14-63. PMID 24674348.

External links

• UBQLN4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)