UGT2A2

UGT2A2
Identifiers
Aliases UGT2A2
External IDs MGI: 3576095 HomoloGene: 115736 GeneCards: UGT2A2
Orthologs
Species Human Mouse
Entrez

574537

552899

Ensembl

ENSG00000271271

ENSMUSG00000029268

UniProt

Q9Y4X1

Q6PDD0

RefSeq (mRNA)

NM_001301233
NM_001105677

NM_001024148

RefSeq (protein)

NP_001019319.1

Location (UCSC) Chr 4: 69.59 – 69.64 Mb Chr 5: 87.46 – 87.48 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

'UDP glucuronosyltransferase 2 family, polypeptide A2, also known as UGT2A2, is an enzyme that in humans is encoded by the UGT2A2 gene.[3][4]

Function

The olfactory neuroepithelium, which lines the posterior nasal cavity, is exposed to a wide range of odorants and airborne toxic compounds. Odorants, which are mostly small lipophilic molecules, enter the mucus flow and reach the odorant receptors on sensory neurons. Odorant sensing is generally a transient process, requiring an effective signal termination, which could be provided by biotransformation of the odorant in the epithelial supporting cells. Xenobiotic-metabolizing enzymes in the olfactory epithelium have been suggested to catalyze inactivation and facilitate elimination of odorants.[3]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. 1 2 "Entrez Gene: UDP glucuronosyltransferase 2 family, polypeptide A2".
  4. ↑ Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, Nebert DW (October 2005). "Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily". Pharmacogenet. Genomics. 15 (10): 677–85. doi:10.1097/01.fpc.0000173483.13689.56. PMID 16141793.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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